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Mutations in different genes are responsible for the clinical manifestation. While mutations in the keratin 5 (<jats:italic>KRT5<\/jats:italic>) gene favor a reticular distribution pattern, mutations in the <jats:italic>POGLUT1<\/jats:italic> gene lead to a disseminated, papular clinical picture. Acantholytic variants of Dowling\u2010Degos disease have historically been referred to as Galli\u2010Galli disease, but our case study shows that the histopathological changes can vary even within a single patient. To date, no standardized therapy concept exists. The main focus is on keratolytic measures, with varying response. New therapeutic approaches using laser technology appear to be a promising treatment option.<\/jats:p>","DOI":"10.1111\/ddg.14897","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T11:35:01Z","timestamp":1667216101000},"page":"1423-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Disseminated papular variant of Dowling\u2010Degos disease: Histopathological features in <i>POGLUT1<\/i> mutation"],"prefix":"10.1111","volume":"20","author":[{"given":"Katharina","family":"Papadopoulou","sequence":"first","affiliation":[{"name":"Dermatologikum Hamburg Stephansplatz\u00a05  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syrus","family":"Karsai","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg Stephansplatz\u00a05  Hamburg Germany"},{"name":"Department of Dermatology and Venereology University Hospital Hamburg\u2010Eppendorf  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