{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T17:19:57Z","timestamp":1707671997642},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical aluminum salts are a commonly used remedy for excessive axillary perspiration. To the contrary, less is known about their anhidrotic potential in the groin. This study sought to compare the anhidrotic efficacy and tolerability of an aluminum chloride\u2010based antiperspirant to an innovative aluminum lactate\u2010based antiperspirant in healthy study participants presenting with excessive axillary and inguinal perspiration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants and Methods<\/jats:title><jats:p>Fifty participants were enrolled in this open open\u2010labeled, randomized, controlled trial. Following a baseline assessment, efficacy was analyzed at two time points throughout the study period by means of four physiological parameters (pH value, transepidermal water loss, gravimetric analysis, Minor test) and two questionnaires (Dermatology Life Quality Index, Hyperhidrosis Disease Severity Scale). Tolerability was evaluated via symptom diaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both study preparations were comparably effective in reducing axillary and inguinal perspiration and exhibited increasing effectiveness over time. In both treatment regions, the aluminum lactate\u2010based antiperspirant had a more favorable tolerability profile than the aluminum chloride\u2010based antiperspirant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Due to its comparable efficacy and \u2013 most noticeably in the groin \u2013 superior tolerability, this study supports the use of topical aluminum lactate as a first\u2010line option to control excessive axillary and inguinal perspiration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14898","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T09:34:05Z","timestamp":1670664845000},"page":"1589-1601","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of a novel aluminum lactate\u2010based with an aluminum chloride\u2010based antiperspirant in excessive axillary and inguinal perspiration: first randomized controlled trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Constantin","family":"L\u00fctgerath","sequence":"first","affiliation":[{"name":"Dermatologikum Hamburg GmbH  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Biomathematics University Medical Centre  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Faulhaber","sequence":"additional","affiliation":[{"name":"MVZ Hautzentrum am Kalten Markt GmbH Schw\u00e4bisch Gm\u00fcnd  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syrus","family":"Karsai","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg GmbH  Hamburg Germany"},{"name":"Department of Dermatology University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"S491","article-title":"Hyperhidrosis and its impact on those living with it","volume":"24","author":"Lenefsky M","year":"2018","journal-title":"Am J Manag Care"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/ddg.13579","article-title":"Update of the S1 guidelines on the definition and treatment of primary hyperhidrosis","volume":"16","author":"Rzany B","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/ddg.12623","article-title":"Repetitive injections of botulinum toxin A continuously increase the duration of efficacy in primary axillary hyperhidrosis: a retrospective analysis in 101 patients","volume":"13","author":"Brehmer F","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_5_1","first-page":"32","article-title":"Hyperhidrosis \u2013 causes and treatment of enhanced sweating","volume":"106","author":"Schlereth T","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351292"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SM02510B"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-018-4265-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04173.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(09)06"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2018.01.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.761344"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2003.12.028"},{"key":"e_1_2_9_16_1","unstructured":"Regulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. 2009. 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