{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:51:26Z","timestamp":1784134286098,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Darier disease (DD) and Hailey\u2010Hailey disease (HHD) are rare disorders caused by mutations in the ATPase, Sarcoplasmic\/Endoplasmic Reticulum Ca<jats:sup>2+<\/jats:sup> Transporting 2 (<jats:italic>ATP2A2<\/jats:italic>) and ATPase Ca<jats:sup>2+<\/jats:sup> Transporting Type 2C, Member 1 (<jats:italic>ATP2C1<\/jats:italic>) gene, respectively, which lead to a disturbance of calcium metabolism in keratinocytes. Clinically, this is reflected by an impairment of keratinization. Histologically, acantholysis with variable degrees of dyskeratosis and parakeratosis is observed. Both diseases can usually be differentiated clinically, histopathologically and genetically. However, their routine distinction might be challenging since some patients do not harbor <jats:italic>ATP2A2<\/jats:italic> or <jats:italic>ATP2C1<\/jats:italic> mutations. To solve this diagnostic challenge, we studied the differential expression of two proteins of store\u2010operated calcium entry (SOCE), stromal interaction molecule\u00a01 (STIM1) and calcium release\u2010activated calcium modulator\u00a01 (ORAI1), by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Five individuals with ambiguous diagnostic findings and eight controls with an unambiguous diagnosis were studied clinically, histologically, genetically, and by immunohistochemistry for STIM1 and ORAI1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DD patients consistently showed a cytoplasmic STIM1 expression while patients with HHD revealed a membrane\u2010associated staining pattern. In contrast, ORAI1 did not show a differential expression pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest subcellular compartmentalization of STIM1 as novel biomarker for the distinction of the two disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14912","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:53:52Z","timestamp":1669686832000},"page":"1613-1619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Subcellular compartmentalization of STIM1 for the distinction of Darier disease from Hailey\u2010Hailey disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Hedwig","family":"Stanisz","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen 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University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen 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