{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:42:29Z","timestamp":1774687349306,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Radiotherapy of elderly, frail patients with facial skin cancer in proximity to critical organs is challenging. This is the first report on clinical experience with facial skin cancer treated by individualized 3D\u2010printer\u2010based mold high\u2010dose\u2010rate (HDR) brachytherapy (BT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Fifteen patients not eligible for radical surgery or definitive external beam radiotherapy (EBRT) were treated with 3D\u2010printer\u2010based mold HDR\u2010BT. Patient selection and treatment were in accordance with multidisciplinary tumor board recommendations. Clinical response, toxicity and cosmesis were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 77 years. Histology revealed squamous cell carcinoma in seven, basal cell carcinoma in five, melanoma in situ in one, Lentigo maligna in one, and melanoma in one patient, respectively. Median prescription dose was 39\u00a0Gy delivered in once\u2010daily fractions of 3\u00a0Gy. After a median follow\u2010up of 12.2\u00a0months, local recurrence was observed in one patient with melanoma in situ. Apart from one grade\u00a04 cataract, no other &gt;\u00a0grade\u00a02 late toxicity was documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HDR\u2010BT with 3D\u2010printer\u2010based molds for facial skin cancer is a well\u2010tolerated and safe treatment option for elderly, frail patients not eligible for radical surgery or definitive EBRT due to functional inoperability or tumor location.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14944","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T20:19:01Z","timestamp":1674159541000},"page":"35-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Customized 3D\u2010printed molds for high dose\u2010rate brachytherapy in facial skin cancer: First clinical experience"],"prefix":"10.1111","volume":"21","author":[{"given":"Georgios","family":"Chatzikonstantinou","sequence":"first","affiliation":[{"name":"Department of Radiotherapy and Oncology University Hospital Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Diefenhardt","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology University Hospital Goethe University Frankfurt am Main  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer Institute  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Fleischmann","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology University Hospital Goethe University Frankfurt am Main  Frankfurt am Main 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