{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T01:03:17Z","timestamp":1724029397537},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2017, we reported the first life\u2010saving regeneration of virtually an entire epidermis by combined gene and stem cell therapy. Recently, we demonstrated excellent long\u2010term stability of this transgenic epidermis. Skin quality in this experimental approach and its potential application in other conditions were elucidated here regarding long\u2010term outcomes of biomechanical properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Analysis of biomechanical properties including skin elasticity, anisotropy and friction was performed on multiple body sites 24, 36 and 60\u00a0months following transplantation. Firstly, the sites were matched against and compared to remaining stable non\u2010transgenic areas as well as to a control group of 13 healthy subjects. Parameters for skin elasticity, deformation and friction were assessed non\u2010invasively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biomechanical properties of the transgenic epidermis showed encouraging results in comparison to both the remaining stable non\u2010transgenic skin as well as healthy controls. Skin elasticity was comparable to the controls. Skin friction showed some decrease in both transgenic and non\u2010transgenic areas as compared to the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The excellent functional outcomes of the transgenic epidermis demonstrate stable long\u2010term results of this novel combined gene and stem cell therapy for epidermal regeneration. Thus, other applications for this technology, such as treatment of specific burns, should be explored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14978","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T10:26:28Z","timestamp":1676111188000},"page":"245-252","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transgenic skin biomechanical properties following first lifesaving epidermal regeneration using combined gene and cell therapy"],"prefix":"10.1111","volume":"21","author":[{"given":"Burcu","family":"Yeni","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Institute of Musculoskeletal Medicine University Hospital Muenster  Muenster Germany"},{"name":"Department of Plastic Reconstructive and Aesthetic Surgery Hand Surgery Fachklinik Hornheide  Muenster 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of Trauma Hand and Reconstructive Surgery University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Wiebringhaus","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Institute of Musculoskeletal Medicine University Hospital Muenster  Muenster Germany"},{"name":"Department of Plastic Reconstructive and Aesthetic Surgery Hand Surgery Fachklinik Hornheide  Muenster Germany"},{"name":"Division of Plastic Surgery Department of Trauma Hand and Reconstructive Surgery University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Aitzetmueller","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Institute of Musculoskeletal Medicine University Hospital Muenster  Muenster Germany"},{"name":"Department of Plastic Reconstructive and Aesthetic Surgery Hand Surgery 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