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This study assesses SARS\u2010CoV\u20102 vaccination\u2010associated skin reactions, severity, treatment, course, eliciting vaccines, allergy test results and tolerance to revaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Single\u2010institutional, non\u2010interventional study of dermatologists assessing cutaneous manifestations in 83 patients in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>93 reactions were presented. Manifestations clustered into immediate (n\u00a0=\u00a051, 54.8%) and delayed hypersensitivity reactions (n\u00a0=\u00a010, 10.8%), chronic inflammatory skin diseases (n\u00a0=\u00a013, 14.0%), reactivation of latent herpes virus infection (pityriasis rosea\/herpes zoster; n\u00a0=\u00a09; 9.7%) and others (n\u00a0=\u00a010, 10.8%). Vaccination was associated with new (76.3%) \u2013 mostly hypersensitivity reactions \u2013 or exacerbation of known skin diseases (23.7%), in this case predominantly chronic inflammatory skin diseases. Reactions occurred primarily within the first week (72.8%) and after first vaccination (62.0%). Treatment was required in 83.9% and hospitalization in 19.4%. In 48.8% revaccination led to recurrence of the same reactions. Disease was ongoing at last consultation in 22.6%, primarily in chronic inflammatory skin diseases. Allergy tests were performed in 15 patients (18.1%) and resulted negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It can be assumed that vaccination may trigger immune activation\u2010related reactions especially in those patients predisposed to develop respective skin diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14987","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T13:24:58Z","timestamp":1678368298000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous reactions following COVID\u201019 vaccination assessed by dermatologists: a single\u2010institutional study in Germany"],"prefix":"10.1111","volume":"21","author":[{"given":"Rosi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Mathes","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Claussen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Brockow","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein School of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO. 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