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However, in real life, a high proportion of patients either do not experience the clinical improvement observed in clinical trials or develop a secondary loss of efficacy. This may be a result of unrecognized endotypes of psoriasis that need to be characterized in greater depth to enable selection of an appropriate therapy. Eczematized psoriasis, which occurs in approximately 5\u201310% of patients with psoriasis, is an often\u2010neglected variant of psoriasis. The term \u201ceczematized psoriasis\u201d refers to patients developing psoriasis with similarities to eczema. These patients typically present with severe itching, and skin biopsies often reveal eosinophil granulocytes, serum crusts, or spongiosis, which are frequently observed in eczema. From an immunological perspective, additional signaling pathways that are responsible for eczema reactions might be activated in eczematized psoriasis compared to classical plaque psoriasis. This review summarizes the key clinical, histological, and immunological features of eczematized psoriasis, proposes diagnostic criteria, and evaluates the therapeutic options for eczematized psoriasis.<\/jats:p>","DOI":"10.1111\/ddg.14991","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T10:24:23Z","timestamp":1676111063000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Eczematized psoriasis \u2013 a frequent but often neglected variant of plaque psoriasis"],"prefix":"10.1111","volume":"21","author":[{"given":"Felix","family":"Lauffer","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilian","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology Department of 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