{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T14:50:40Z","timestamp":1751554240114},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To evaluate the association between psoriasis and migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p><jats:italic>MEDLINE<\/jats:italic>, <jats:italic>Embase<\/jats:italic>, and <jats:italic>the Cochrane Central Register of Controlled Trials<\/jats:italic> were searched for relevant observational studies from their respective inception to May 1, 2022. A random\u2010effects model meta\u2010analysis was performed to calculate the risk estimates quantifying the associations between psoriasis and migraine. We also performed a sensitivity analysis by including only studies with adjusted risk estimates and a subgroup analysis according to the severity of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 9 studies with 6,742,075 participants. The meta\u2010analysis illustrated increased odds for prevalent migraine among patients with psoriasis (pooled OR: 1.69, 95% CI: 1.26\u20132.28) and increased odds for prevalent psoriasis among those with migraine (OR: 1.88, 95% CI: 1.32\u20133.67). A subgroup analysis of cohort studies demonstrated an increasingly higher risk of incident migraine in patients with mild psoriasis and severe psoriasis (IRR being 1.37 (95% CI 1.30\u20131.44) and 1.55 (95% CI 1.29\u20131.86), respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis revealed significant bidirectional associations between migraine and psoriasis. Greater severity of psoriasis appears to be associated with a higher risk of developing migraine. Clinicians should evaluate symptoms of migraine in patients with psoriasis and provide proper treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14994","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T09:34:41Z","timestamp":1681724081000},"page":"493-502","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bidirectional associations between psoriasis and migraine: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"I\u2010Hsin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital  Linkou Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Kai","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital  Linkou Taoyuan 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