{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:42:34Z","timestamp":1783539754542,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The increasing use of biologics in the treatment of inflammatory diseases has led to more cases of leishmaniasis in patients subjected to iatrogenic immunosuppression. The main objective was to describe the characteristics of the patients with cutaneous (CL) or mucocutaneous (MCL) leishmaniasis who were receiving a biological therapy at the time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A multicenter retrospective study was design based on a cohort of patients diagnosed with CL or MCL. All patients who were being treated with biologicals were included. For each case, two matched non\u2010exposed patients were included for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>38 patients were diagnosed with CL or MCL while being treated with tumor necrosis factor alpha (TNF\u2010\u03b1) inhibitors. Leishmaniasis presented more frequently as a plaque (58.3%) with a larger median lesion size (2.5\u00a0cm), ulceration (92.1%), and required a greater median number of intralesional meglumine antimoniate infiltrations (3 doses) (<jats:italic>P<\/jats:italic> &lt;\u00a00.05) than in non\u2010exposed patients. We found no systemic involvement in patients being treated with anti\u2010TNF\u2010\u03b1. We did not find differences regarding the treatment characteristics whether biologic therapy was modified or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although management should be individualized, maintenance of biologic therapy does not seem to interfere with treatment of CL or MCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15007","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:12:18Z","timestamp":1681283538000},"page":"473-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathological characteristics of cutaneous and mucocutaneous leishmaniasis in patients treated with TNF\u2010\u03b1 inhibitors"],"prefix":"10.1111","volume":"21","author":[{"given":"Rodolfo David","family":"Palacios\u2010Diaz","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sahuquillo\u2010Torralba","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicen\u00e7","family":"Rocamora\u2010Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital de Manacor  Illes Baleares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca de","family":"Unamuno\u2010Bustos","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Salavert\u2010Lleti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Santos\u2010Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Doctor Peset  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Quintero","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital de Manacor  Illes Baleares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Garc\u00edas\u2010Ladaria","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Son Espases  Illes Baleares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Vila\u2010Payeras","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Son Ll\u00e0tzer Palma de Mallorca  Illes Baleares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Mart\u00ednez\u2010Dom\u00e9nech","sequence":"additional","affiliation":[{"name":"Dermatology Department. 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