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In this review, we summarize the main features of current psoriasis research with emphasis on pathophysiological processes and the milestones in the approval of various biologics and small molecule drugs. Thus, through psoriasis research, we are gaining a better understanding of the interplay between the components of the innate and adaptive immune systems. New therapeutics interfere with crucial regulatory networks. Based on current knowledge, we outline what we believe to be some of the most important future research directions and therapeutic and clinical developments in psoriasis. These span multiple areas, ranging from the study of genetic, epigenetic, cellular, and immunological mechanisms to studies of particular clinical forms of psoriasis, individual systemic effects of the disease and its treatment, and the incorporation of large connected data sets and artificial intelligence. The goal is to understand psoriasis holistically, from the molecular to the organismic and societal levels, in order to develop individualized prevention and treatment strategies. Despite impressive progress, psoriasis research must continue to evolve at both the smallest and largest scales to comprehensively address the needs of both physicians and patients.<\/jats:p>","DOI":"10.1111\/ddg.15033","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T07:33:47Z","timestamp":1680680027000},"page":"363-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Current developments and perspectives in psoriasis"],"prefix":"10.1111","volume":"21","author":[{"given":"Michael P.","family":"Sch\u00f6n","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute for Occupational Dermatology University Medical Center G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wilsmann\u2010Theis","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University Hospital Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13071064"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1610-0387.2003.t01-1-02024.x"},{"issue":"7","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/ddg.14777","article-title":"Resistant psoriasis associated with LRBA deficiency: A case report","volume":"20","author":"Amer MA","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"issue":"4","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/ddg.14425","article-title":"Non\u2010alcoholic fatty liver disease and psoriasis \u2013 is there a shared proinflammatory network?","volume":"19","author":"Heitmann J","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14469_g"},{"issue":"10","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/ddg.14857","article-title":"Acute generalized pustular psoriasis successfully treated with the IL\u201023p19 antibody risankizumab","volume":"20","author":"Heyer S","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"issue":"9","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/ddg.14832","article-title":"Biologics for pediatric moderate\u2010to\u2010severe plaque psoriasis: a systematic review and network meta\u2010analysis","volume":"20","author":"Huang IH","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"issue":"1","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ddg.14668","article-title":"JAK\u2010inhibitors in dermatology \u2013 small molecules, big impact? 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