{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:03:43Z","timestamp":1692767023544},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Bull\u00f6se Autoimmundermatosen (BAID) sind eine heterogene Gruppe von etwa einem Dutzend Erkrankungen, die klinisch durch Erosionen und Blasen und immunpathologisch durch Autoantik\u00f6rper gegen Strukturproteine der Haut oder Transglutaminase 2\/3 charakterisiert sind. Die Diagnostik der BAID hat in der letzten Dekade enorme Fortschritte gemacht durch die Verf\u00fcgbarkeit standardisierter serologischer Nachweismethoden, welche in Kenntnis des klinischen Bildes die Diagnose bei der \u00fcberwiegenden Mehrheit der Patienten erlaubt. Durch die Entwicklung verschiedener <jats:italic>In\u2010vitro<\/jats:italic>\u2010 und <jats:italic>In\u2010vivo<\/jats:italic>\u2010Modelle zu den h\u00e4ufigsten BAID, zum Beispiel bull\u00f6ses Pemphigoid, Pemphigus vulgaris, Schleimhautpemphigoid sowie der seltenen Epidermolysis bullosa acquisita, ist es m\u00f6glich, Schl\u00fcsselmolek\u00fcle und Entz\u00fcndungswege zu identifizieren und die Wirkung neuer antientz\u00fcndlicher Therapien pr\u00e4klinisch zu evaluieren. Die Zulassung von Rituximab f\u00fcr den moderaten und schweren Pemphigus vulgaris und die Entwicklung nationaler und internationaler Leitlinien f\u00fcr die h\u00e4ufigsten BAID stellt einen betr\u00e4chtlichen Fortschritt in der Versorgung dieser Patienten dar. Trotzdem ist das limitierte therapeutische Armamentarium die gr\u00f6\u00dfte Herausforderung f\u00fcr das Management der BAID. Mehrere randomisierte kontrollierte klinische Studien der Phasen\u00a0II und III geben jedoch Anlass zur Hoffnung, dass in den n\u00e4chsten Jahren neue wirksame und sichere Therapieoptionen zur Verf\u00fcgung stehen werden. Die vorliegende \u00dcbersichtsarbeit fasst Epidemiologie, Klinik, Diagnostik, Pathophysiologie und Therapie der BAID zusammen und gibt einen Ausblick auf den aktuellen diagnostischen und therapeutischen Bedarf sowie zuk\u00fcnftige Entwicklungen.<\/jats:p>","DOI":"10.1111\/ddg.15046_g","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T09:32:56Z","timestamp":1681810376000},"page":"405-413","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bull\u00f6se Autoimmundermatosen"],"prefix":"10.1111","volume":"21","author":[{"given":"Maike M.","family":"Holtsche","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Allergologie und Venerologie Universit\u00e4tsklinik Schleswig\u2010Holstein  Campus L\u00fcbeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Boch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Allergologie und Venerologie Universit\u00e4tsklinik Schleswig\u2010Holstein  Campus L\u00fcbeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Allergologie und Venerologie Universit\u00e4tsklinik Schleswig\u2010Holstein  Campus L\u00fcbeck"},{"name":"L\u00fcbecker Institut f\u00fcr Experimentelle Dermatologie Universit\u00e4t L\u00fcbeck"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31778-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.26"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8662-z"},{"key":"e_1_2_8_6_1","first-page":"413","article-title":"Bullous Autoimmune dermatoses \u2013 clinical features, diagnostic evaluation, and treatment options","volume":"118","author":"Beek NV","year":"2021","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-018-8986-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06976_supp.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17107"},{"key":"e_1_2_8_10_1","first-page":"868","volume-title":"Harper's Textbook of Pediatric Dermatology, chapter 73","author":"Beek N","year":"2020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16467"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.46"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01863-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14393"},{"key":"e_1_2_8_15_1","first-page":"1","volume-title":"Rook's Textbook of Dermatology, part 3, chapter 50","author":"Schmidt E","year":"2016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.1099"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/ddg.14905","article-title":"S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid","volume":"20","author":"Hofmann SC","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17397"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-017-4089-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103036"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1221343"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17183"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/ddg.14738","article-title":"Comorbid diseases among bullous pemphigoid patients in Germany: new insights from a case\u2010control study","volume":"20","author":"Martin E","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/ddg.14852","article-title":"Association between bullous pemphigoid and psychiatric disorders: A systematic review and meta\u2010analysis","volume":"20","author":"Huang IH","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00238"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.547"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.773720"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.4773"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/ddg.14595","article-title":"Comorbid diseases associated with pemphigus: a case\u2010control study","volume":"19","author":"Bardazzi F","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.1587"},{"key":"e_1_2_8_32_1","first-page":"516","article-title":"S2k guidelines for the treatment of pemphigus vulgaris\/foliaceus and bullous pemphigoid: 2019 update","volume":"18","author":"Schmidt E","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.022"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.701809"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.03.037"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200521386"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01720.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.09.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2862"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.12.021"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00087-8"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.11.029"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13637"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/ddg.14695","article-title":"Disease progression and response to therapy in pemphigus based on a registry","volume":"20","author":"Pieper J","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_45_1","first-page":"713","article-title":"S2k guideline for the diagnosis of pemphigus vulgaris\/foliaceus and bullous pemphigoid","volume":"13","author":"Schmidt E","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17395"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18220"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591971"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1111172"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15233"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14986"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.04.009"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.865241"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15046_g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:16:32Z","timestamp":1692702992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15046_g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/ddg.15046_g"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15046_g","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}