{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:30:41Z","timestamp":1718411441804},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die atopische Dermatitis (AD) ist eine chronisch\u2010entz\u00fcndliche Hauterkrankung, zu der in den vergangenen Jahren viele neue Erkenntnisse durch ein besseres Verst\u00e4ndnis vor allem von Pathophysiologie, Begleiterkrankungen und Therapeutika gewonnen wurden. In dieser \u00dcbersichtsarbeit werden hierzu neue und praxisrelevante Ergebnisse aus der aktuellen Forschung vorgestellt. In der Diagnostik der AD und zu verschiedenen Subtypen wurden viele Studien durchgef\u00fchrt, dennoch hat sich hier bislang kein diagnostischer Biomarker oder klinischer Pr\u00e4diktor f\u00fcr ein Therapieansprechen in der klinischen Routine etabliert. F\u00fcr die topische Behandlung sind einige Wirkstoffe wie Januskinase (JAK)\u2010Inhibitoren in fortgeschrittenen Stadien der klinischen Pr\u00fcfung oder bereits in anderen L\u00e4ndern zugelassen, die wahrscheinlich auch bei uns bald zur Behandlung von bestimmten Ekzem\u2010Unterformen zur Verf\u00fcgung stehen werden. Die aktuellen Systemtherapeutika umfassen zwei Antik\u00f6rper zur Inhibition der Interleukin (IL)\u20104\/13\u2010Signalkaskaden sowie drei JAK\u2010Inhibitoren mit etwas unterschiedlichen Effektivit\u00e4ts\u2010 und Sicherheitsprofilen. Unter den in der Entwicklung fortgeschrittenen Antik\u00f6rpertherapien zur AD finden sich als vielversprechende neue Ziele die Blockade der IL\u201031\u2010Wirkung, des Neurokinin\u20101\u2010Rezeptors auf sensorischen Neuronen sowie die Inhibition der OX40\/OX40L\u2010Achse zur Interaktion von kutanen dendritischen Zellen und T\u2010Lymphozyten. Prim\u00e4re Pr\u00e4vention und Modulation des sequenziellen Krankheitsgeschehens sowie Effekte auf Begleiterkrankungen durch fr\u00fchzeitige therapeutische Intervention werden wichtige Fragen in der zuk\u00fcnftigen Forschung zur AD sein.<\/jats:p>","DOI":"10.1111\/ddg.15050_g","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T09:32:56Z","timestamp":1681810376000},"page":"349-354","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atopische Dermatitis \u2013 Perspektiven und unerf\u00fcllte medizinische Bedarfe"],"prefix":"10.1111","volume":"21","author":[{"given":"Timo","family":"Buhl","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsmedizin G\u00f6ttingen"},{"name":"Nieders\u00e4chsisches Institut f\u00fcr Berufsdermatologie Universit\u00e4t G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Werfel","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Immundermatologie und Allergieforschung Klinik f\u00fcr Dermatologie und Allergologie Medizinische Hochschule Hannover"},{"name":"Nieders\u00e4chsisches Institut f\u00fcr Berufsdermatologie Medizinische Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.8.3.163"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13765"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.04.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14318"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/ddg.14678","article-title":"Characterization of the effects on pruritus by novel treatments for atopic dermatitis","volume":"20","author":"Bonnekoh H","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14709_g"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.02.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15108"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.044"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.10.060"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2217"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09743.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02164-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00610-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ddg.14668","article-title":"JAK\u2010inhibitors in dermatology \u2013 small molecules, big impact? 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