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The diseases are rare and the diagnosis, which always requires a clinical\u2010pathological correlation, is often delayed, especially in early forms of mycosis fungoides. The prognosis of mycosis fungoides depends on its stage and is usually favorable in the early stages. Clinically relevant prognostic parameters are missing and their development is the subject of current clinical research. S\u00e9zary syndrome, characterized by initial erythroderma and blood involvement, is a disease with a high mortality rate, in which good responses can now be achieved in many cases with new treatment options. The pathogenesis and immunology of the diseases is heterogeneous, with recent results pointing primarily to changes in specific signal transduction pathways that may be suitable as future treatment targets. Current therapy for mycosis fungoides and S\u00e9zary syndrome is primarily palliative with topical and systemic options either used alone or in combination. Only with allogeneic stem cell transplantation durable remissions can be achieved in selected patients. Similar to other areas of oncology, the development of new therapies for cutaneous lymphomas is currently changing from relatively untargeted empiricism to disease\u2010specific, targeted pharmacotherapy based on knowledge from experimental research.<\/jats:p>","DOI":"10.1111\/ddg.15051","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T11:15:45Z","timestamp":1679915745000},"page":"386-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mycosis fungoides and S\u00e9zary syndrome \u2013 Review and outlook"],"prefix":"10.1111","volume":"21","author":[{"given":"Johanna","family":"Latzka","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital of St. P\u00f6lten Karl Landsteiner University of Health Sciences  St. P\u00f6lten Austria"},{"name":"Karl Landsteiner Institute of Dermatological Research  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Trautinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital of St. P\u00f6lten Karl Landsteiner University of Health Sciences  St. P\u00f6lten Austria"},{"name":"Karl Landsteiner Institute of Dermatological Research  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_8_4_1","first-page":"1307","article-title":"Mycosis fungoides and Sezary syndrome","volume":"19","author":"Jonak C","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14509"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5526"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17258"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.7665"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.01.076"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-251926"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-772996"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.23.4322"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.227"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163661"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.08.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83352-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009655"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00296-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202115200"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22326.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.02.027"},{"key":"e_1_2_8_23_1","first-page":"537","article-title":"S2k\u2010Leitlinie \u2013 Kutane Lymphome (ICD10 C82\u2010C86): Update 2021","volume":"20","author":"Dippel E","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy133"},{"key":"e_1_2_8_25_1","unstructured":"Primary cutaneous lymphoma version 1.2023. 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