{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:37:21Z","timestamp":1789537041323,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Various interventions have been applied to treat molluscum contagiosum, but benefits and efficacy remain unclear. To assess the comparative efficacy and safety of interventions for molluscum contagiosum, a network meta\u2010analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Embase, PubMed, and the Cochrane Library were searched for articles published between January 1, 1990, and November 31, 2020. Eligible studies were randomized clinical trials (RCTs) of interventions in immunocompetent children and adults with genital\/non\u2010genital molluscum contagiosum lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve interventions from 25 RCTs including 2,123 participants were assessed. Compared with the placebo, ingenol mebutate had the most significant effect on complete clearance (odds ratio [OR] 117.42, 95% confidence interval [CI] 6.37\u20132164.88), followed by cryotherapy (OR 16.81, 95% CI 4.13\u201368.54), podophyllotoxin (OR 10.24, 95% CI 3.36\u201331.21), and potassium hydroxide (KOH) (OR 10.02, 95% CI 4.64\u201321.64). Data on adverse effects were too scarce for quantitative synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ingenol mebutate, cryotherapy, podophyllotoxin, and KOH were more effective than the other interventions in achieving complete clearance, but safety concerns regarding ingenol mebutate have recently been reported. Due to the possibility of spontaneous resolution, observation is also justified for asymptomatic infection. Factors including adverse effects, cost, patient preference, and medical accessibility should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15063","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T09:58:40Z","timestamp":1684403920000},"page":"587-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative efficacy of treatments for molluscum contagiosum: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Yuan\u2010Chen","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei City Hospital  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Ju","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei City Hospital  Taipei City Taiwan"},{"name":"Department of Dermatology National Taiwan 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