{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:40:41Z","timestamp":1789476041056,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The coronavirus SARS\u2010CoV\u20102, which is the cause of COVID\u201019 disease in infected patients, has led to an ongoing worldwide pandemic. Although SARS\u2010CoV\u20102 vaccination had a dramatic positive effect on the course of COVID\u201019, there has been increasing evidence of adverse effects after SARS\u2010CoV\u20102 vaccination. This meta\u2010analysis highlights the association between SARS\u2010CoV\u20102 vaccination and <jats:italic>de novo<\/jats:italic> induction or aggravation of inflammatory and autoimmune skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A systematic meta\u2010analysis of the literature on new onset or worsening of inflammatory and autoimmune diseases after SARS\u2010CoV\u20102 vaccination was performed according to the PRISMA guidelines. The search strategy included following terms: \u201cCOVID\u201019\/SARS\u2010CoV\u20102 vaccine bullous pemphigoid\/pemphigus vulgaris\/systemic lupus erythematosus\/dermatomyositis\/lichen planus\/leukocytoclastic vasculitis.\u201d Moreover, we describe representative cases from our dermatology department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The database\u2010search in MEDLINE identified 31 publications on bullous pemphigoid, 24 on pemphigus vulgaris, 65 on systemic lupus erythematosus, nine on dermatomyositis, 30 on lichen planus, and 37 on leukocytoclastic vasculitis until June 30th, 2022. Severity and response to treatment varied among the described cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis highlights a link between SARS\u2010CoV\u20102 vaccination and new onset or worsening of inflammatory and autoimmune skin diseases. 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