{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:05:04Z","timestamp":1773090304553,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Necrobiosis lipoidica (NL) ist eine seltene granulomat\u00f6se Erkrankung mit scharf begrenzten, teleangiektatischen, braun\u2010roten Plaques mit atroph\u2010gelblichen Zentren, die zu Ulzerationen neigen und haupts\u00e4chlich an den Schienbeinen auftreten. Bei Kindern ist NL sehr selten, jedoch sind die Therapieresistenz, das problematische kosmetische Erscheinungsbild, die schmerzhaften Ulzerationen und die m\u00f6gliche Entwicklung von Plattenepithelkarzinomen besonders herausfordernd f\u00fcr diese Altersgruppe. Unsere Literaturrecherche inkludiert 29 Berichte \u00fcber NL bei Patienten unter 18 Jahren, die seit 1990 auf PubMed, EMBASE und Medline publiziert wurden. Das mittlere Alter war 14,3 Jahre mit weiblicher Pr\u00e4dominanz von 2\u00a0:\u00a01 und hoher Pr\u00e4valenz von Diabetes mellitus (80%). Aus den Daten geht hervor, dass hochpotente topische Steroide bis zu zweimal t\u00e4glich Behandlung erster Wahl sind. Therapierefrakt\u00e4re F\u00e4lle k\u00f6nnen auf Tacrolimus umgestellt werden. Ulzerationen profitieren von phasenadaptierter Wundversorgung und antientz\u00fcndlichen medizinischen Verb\u00e4nden wie mit medizinischem Honig. Das Hinzuf\u00fcgen einer hyperbaren Sauerstoffbehandlung zur lokalen oder systemischen Therapie kann bei schwer behandelbaren ulzerierten L\u00e4sionen in Betracht gezogen werden. Therapieresistente F\u00e4lle k\u00f6nnen umgestellt werden auf topische Photochemotherapie oder systemische Behandlung mit TNF\u2010alpha\u2010Inhibitoren, systemischen Steroiden (bevorzugt bei Patienten ohne Diabetes), Pentoxifyllin oder Hydroxychloroquin. Necrobiosis lipoidica in der Kindheit ist mit \u00fcber 40% fehlgeschlagenen Therapieversuchen schwer zu behandeln, weshalb weitere Forschung \u00fcber Patientenregister empfohlen wird.<\/jats:p>","DOI":"10.1111\/ddg.15137_g","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:36:55Z","timestamp":1697506615000},"page":"1120-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Literaturrecherche zur Therapie der Necrobiosis lipoidica in der Kindheit"],"prefix":"10.1111","volume":"21","author":[{"given":"Anna","family":"Schiefer\u2010Niederkorn","sequence":"first","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Dermatologie und Venerologie Medizinische Universit\u00e4t Graz  Graz \u00d6sterreich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Sadoghi","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr 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