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Therapeutic options, pathophysiology and diagnosis continue to be investigated, with considerable progress in HAE over the last few decades. For all patients with bradykinin\u2010mediated angioedema, there are several medications that should be avoided or administered with caution. Some of the triggering medications are well known, while others are suspected or of unknown significance. A common denominator is that there is no approved therapy for bradykinin\u2010mediated angioedema as a drug side effect. Some medications, such as tissue plasminogen activator, have a higher incidence of angioedema with potential airway compromise than ACE inhibitors, although this fact is widely underappreciated. In this review, we aim to summarize what is currently known and recommended about concomitant medication in HAE patients and the interaction of other bradykinin\u2010influencing drugs.<\/jats:p>","DOI":"10.1111\/ddg.15154","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T03:44:38Z","timestamp":1690170278000},"page":"1283-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Concomitant medication in patients with bradykinin\u2010mediated angioedema \u2013 there's more than ACE inhibitors"],"prefix":"10.1111","volume":"21","author":[{"given":"Robin","family":"Lochbaum","sequence":"first","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology Head and Neck Surgery Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of 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