{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T23:12:10Z","timestamp":1722640330751},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The melanoma guideline is mainly based on the AJCC stage. There is no difference according to histological subtypes such as superficial spreading melanoma (SSM), lentigo maligna melanoma (LMM) or nodular malignant melanoma (NM). We aimed to evaluate whether patients with LMM have a different clinical course from patients with SSM\/NM. This is particularly important as adjuvant anti\u2010PD\u20101 therapy is approved for stage IIB and IIC melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Data were extracted from the Central Registry of Malignant Melanoma. Only patients with LMM, SSM, and NM of the head and neck with primary diagnosis between 01\/01\/2000 and 12\/31\/2019 were included. Progression\u2010free survival (PFS), melanoma\u2010specific survival (MSS), and pattern of metastases were analyzed for the LMM group compared to SSM\/NM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LMM cohort (n\u00a0=\u00a0902) had significantly better MSS than the SSM\/NM cohort (n\u00a0=\u00a0604). There was no difference in PFS. The 5\u2010year MSS of the stage II LMM cohort was 88.5% (95% CI 81.4\u201095.6) compared to 79.7% (95% CI 72.8\u201086.6) in the stage II SSM\/NM cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It does not appear appropriate to use adjuvant therapy in stage II LMM patients to the same extent as in patients with SSM\/NM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15164","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T03:44:45Z","timestamp":1690170285000},"page":"1137-1146","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognosis in stage\u00a0II melanoma of the head and neck depends on the histological subtype"],"prefix":"10.1111","volume":"21","author":[{"given":"Sophie","family":"Jasper","sequence":"first","affiliation":[{"name":"Department of Dermatology Center for Dermatooncology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Keim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatooncology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Leiter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatooncology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatooncology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatooncology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Forschner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatooncology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504030"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0809"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30497-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30388-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4514"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802357"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708539"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00562-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21409"},{"key":"e_1_2_8_15_1","unstructured":"Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK AWMF). 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