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Initially introduced as a new therapeutic modality for the treatment of patients with cutaneous T\u2010cell lymphoma, the indications for the use of ECP have expanded to include hematology and transplantation immunology. Extracorporeal photopheresis has found its place in the treatment plan of cutaneous T\u2010cell lymphoma, systemic sclerosis, graft\u2010versus\u2010host disease, organ transplantation such as heart and lung, sometimes as first\u2010line therapy and very often in combination with various systemic immunosuppressive therapies. The procedure basically consists of three steps: leukapheresis, photoactivation and reinfusion. The following article presents possible theories about the mechanism of action, which is not yet fully understood, and discusses the five most common indications for ECP treatment with corresponding therapy recommendations.<\/jats:p>","DOI":"10.1111\/ddg.15167","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T06:00:10Z","timestamp":1695103210000},"page":"1369-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mode of action, indications and recommendations on extracorporeal photopheresis (ECP)"],"prefix":"10.1111","volume":"21","author":[{"given":"Ara","family":"Cho","sequence":"first","affiliation":[{"name":"University Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Paulitschke","sequence":"additional","affiliation":[{"name":"University Department of Dermatology Medical 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