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After a comprehensive search of the databases MEDLINE, EMBASE, Web of Science, and the Cochrane Library and Database of Systematic Reviews, we have summarized the available clinical evidence regarding the therapeutic approaches already reported for this entity since its first description in 1967. Additional publications were identified within the references of retrieved papers. Sixty\u2010five articles have been revised, resulting in a total of 73 compatible cases. The histopathological features and different classifications used through history have also been considered, updating and completing the available knowledge. Ultimately, we propose topical treatment with 5\u00a0% 5\u2010fluorouracil formulated with 10\u00a0% salicylic acid as a potential treatment that has been used successfully in a 51\u2010year\u2010old woman at our facility. Further research in form of prospective or comparative studies is encouraged for a better conceptualization of the therapeutics of this disease.<\/jats:p>","DOI":"10.1111\/ddg.15186","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:45:56Z","timestamp":1697438756000},"page":"1447-1454","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple minute digitate hyperkeratosis: 10 years from Caccetta's algorithm. A case report and narrative review"],"prefix":"10.1111","volume":"21","author":[{"given":"Alvaro","family":"Prados\u2010Carmona","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"Prados\u2010Carmona","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ruiz\u2010Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jos\u00e9","family":"Navarro\u2010Trivi\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Contact Eczema and Immunoallergic Diseases Dermatology Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01610060086015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.023"},{"key":"e_1_2_7_4_1","first-page":"51","article-title":"43rd Australasian Annual Scientific Meeting abstracts: An algorithm for the evaluation of multiple digitate keratoses and multiple minute digitate hyperkeratosis: a case report and literature review","author":"Caccetta T","year":"2010","journal-title":"Australas J Dermatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15193"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247448"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb02183.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00570_9.x"},{"issue":"6","key":"e_1_2_7_9_1","first-page":"460","article-title":"Multiple minute digitate hyperkeratoses: report of two cases with an updated review and proposal for a new classification","volume":"9","author":"Ramselaar C","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000140678"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91429-3"},{"issue":"9","key":"e_1_2_7_12_1","first-page":"615","article-title":"Multiple minute hyperkeratoses. 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