{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:10:52Z","timestamp":1781226652484,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous lymphomas (PCL) are rare skin tumors of lymphoproliferative neoplasms and belong to the heterogeneous group of non\u2010Hodgkin's lymphomas. PCL encompass a broad spectrum of clinical and histologic manifestations, with cutaneous T\u2010cell lymphoma (CTCL) being the most common (73%). Due to the rarity of the diseases, population\u2010based studies of care and epidemiology are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Based on anonymized, age\u2010 and sex\u2010adjusted SHI (statutory health insurance) claims data of approximately five million SHI\u2010insured patients, a retrospective analysis was conducted over a six\u2010year period (2012\u20132017) to determine the prevalence, incidence, and lethality in patients with mature\u2010cell T\/NK\u2010cell lymphoma in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,336 patients with T\u2010cell lymphoma were identified during the observation period. The six\u2010year prevalence ranged from 27.35 to 43.58 per 100,000. Patients were 65% male with a mean age of 66 years (SD 15). There were 246 patients (approx. 20%) who died within the 6\u00a0years, up to 7% per year. The calculated incidence in 153 identified patients in 2017 is 3.65 to 3.92 per 100,000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the first time, valid epidemiologic findings of patients with mature T\u2010cell and NK\u2010cell lymphomas were obtained using SHI claims data in Germany. Further analyses are needed to gain a deeper insight into the healthcare reality of patients with this rare disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15187","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:20:53Z","timestamp":1697505653000},"page":"1320-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epidemiology of mature T\/NK\u2010cell lymphomas in Germany \u2013 A representative cross\u2010sectional study based on SHI claims data"],"prefix":"10.1111","volume":"21","author":[{"given":"Chalid","family":"Assaf","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology HELIOS Klinikum Krefeld  Krefeld Germany"},{"name":"Institute for Molecular Medicine Hamburg Medical School  Hamburg Germany"},{"name":"Department of Dermatology HELIOS Klinikum Schwerin University Campus of the Hamburg Medical School  Schwerin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Dobos","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Joint Faculty of Medicine of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immo\u2010Maximilian","family":"Zech","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Doess","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"May","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Jadasz","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06337.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102921"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19644"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2022.104108"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184168"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.7.854"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480701400203"},{"issue":"9","key":"e_1_2_7_10_1","first-page":"1307","article-title":"Mycosis fungoides and S\u00e9zary syndrome","volume":"19","author":"Jonak C","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.06.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25577"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/05GFG3LY3VYCDMEY"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2385.bloodjournal8872385"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"537","article-title":"S2k\u2010Guidelines \u2013 Cutaneous lymphomas (ICD10 C82 \u2010 C86): Update 2021","volume":"20","author":"Dippel E","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.01.076"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05698.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.02.027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.712"},{"key":"e_1_2_7_20_1","unstructured":"Robert Koch\u2010Institut.Bericht zum Krebsgeschehen in Deutschland 2016. 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