{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T13:40:32Z","timestamp":1720446032481},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund<\/jats:title><jats:p>Prim\u00e4re kutane Lymphome sind seltene lymphoproliferative Neoplasien und geh\u00f6ren zur heterogenen Gruppe der Non\u2010Hodgkin\u2010Lymphome. Sie umfassen ein klinisch und histologisch breites Spektrum an Manifestationsformen, wobei kutane T\u2010Zell\u2010Lymphome (CTCL) mit 73% am h\u00e4ufigsten sind. Aufgrund der Seltenheit der Erkrankungen sind bev\u00f6lkerungsbasierte Untersuchungen zur Versorgungssituation und Epidemiologie kaum vorhanden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik<\/jats:title><jats:p>Auf Basis anonymisierter, alters\u2010 und geschlechtsadjustierter GKV\u2010Routinedaten von circa f\u00fcnf Millionen gesetzlich Krankenversicherten wurde im Sechsjahreszeitraum (2012\u20132017) eine retrospektive Analyse zur Bestimmung von Pr\u00e4valenz, Inzidenz und Letalit\u00e4t von Patienten mit reifzelligen T\/NK\u2010Zell Lymphomen in Deutschland durchgef\u00fchrt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Insgesamt 1336 T\u2010Zell\u2010Lymphom\u2010Patienten konnten im Beobachtungszeitraum identifiziert werden. Die Sechsjahres\u2010Pr\u00e4valenz liegt demnach zwischen 27,35 und 43,58 pro 100\u00a0000 Einwohner. Die Patienten waren zu 65% m\u00e4nnlich mit einem durchschnittlichen Alter von 66 Jahren (SD 15). Es verstarben 246 Patienten (circa 20\u00a0%) innerhalb der 6\u00a0Jahre, pro Jahr bis zu 7\u00a0%. Die ermittelte Inzidenz bei 153 identifizierten Patienten im Jahr 2017 liegt bei 3,65 bis 3,92 pro 100\u00a0000 Einwohner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Erstmalig in Deutschland wurden mithilfe von Abrechnungsdaten der gesetzlichen Krankenversicherung (GKV\u2010Routinedaten), valide epidemiologische Erkenntnisse von Patienten mit reifzelligen T\u2010 und NK\u2010Zell Lymphomen gewonnen. Weitere Analysen f\u00fcr tiefergehende Einblicke in die Versorgung der Patienten mit dieser seltenen Erkrankung sind w\u00fcnschenswert.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15187_g","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T08:36:44Z","timestamp":1699605404000},"page":"1320-1328","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiologie reifzelliger T\u2010 und NK\u2010Zell\u2010Lymphome in Deutschland \u2013 Eine repr\u00e4sentative Querschnittanalyse von GKV\u2010Routinedaten"],"prefix":"10.1111","volume":"21","author":[{"given":"Chalid","family":"Assaf","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Venerologie HELIOS Klinikum Krefeld  Krefeld"},{"name":"Institute for Molecular Medicine Medical School Hamburg  Hamburg"},{"name":"Klinik f\u00fcr Dermatologie HELIOS Klinikum Schwerin universit\u00e4rer Campus der Medical School Hamburg  Schwerin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor","family":"Dobos","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin gemeinsame Medizinische Fakult\u00e4t Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immo\u2010Maximilian","family":"Zech","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Doess","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"May","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Jadasz","sequence":"additional","affiliation":[{"name":"Kyowa Kirin GmbH  D\u00fcsseldorf"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06337.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102921"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19644"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2022.104108"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184168"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.7.854"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480701400203"},{"issue":"9","key":"e_1_2_7_10_1","first-page":"1307","article-title":"Mycosis fungoides and S\u00e9zary syndrome","volume":"19","author":"Jonak C","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.06.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25577"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/05GFG3LY3VYCDMEY"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2385.bloodjournal8872385"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"537","article-title":"S2k\u2010Guidelines \u2013 Cutaneous lymphomas (ICD10 C82 \u2010 C86): Update 2021","volume":"20","author":"Dippel E","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.01.076"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05698.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.02.027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.712"},{"key":"e_1_2_7_20_1","unstructured":"Robert Koch\u2010Institut.Bericht zum Krebsgeschehen in Deutschland2016. 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