{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T13:40:35Z","timestamp":1720446035406},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund<\/jats:title><jats:p>Die diagnostische Abkl\u00e4rung des Ulcus cruris ist zeit\u2010 und kostenintensiv. Ziel dieser Studie war es, die Ulkuslokalisation als diagnostisches Kriterium zu bewerten und einen diagnostischen Algorithmus zur Unterst\u00fctzung in der Diagnostik bereitzustellen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik<\/jats:title><jats:p>Die Studie umfasste 277 Patienten mit Ulcera cruris. Es wurden die folgenden f\u00fcnf Gruppen definiert: Ulcus cruris venosum, arterielle Ulzera, gemischte Ulzera, Arteriolosklerose und Vaskulitis. Mittels computergest\u00fctztem Oberfl\u00e4chenrendering wurden die Pr\u00e4dilektionsstellen der verschiedenen Ulkustypen bewertet. Die Ergebnisse wurden in ein multinomiales logistisches Regressionsmodell integriert, um die Wahrscheinlichkeit einer bestimmten Diagnose in Abh\u00e4ngigkeit von Lokalisation, Alter, bilateraler Beteiligung und Anzahl der Ulzera zu berechnen. Zus\u00e4tzlich wurde eine neuronale Netzwerk\u2010Bildanalyse durchgef\u00fchrt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Die Mehrheit der ven\u00f6sen Ulzera fand sich in der medialen Malleolarregion. Arterielle Ulzera waren am h\u00e4ufigsten auf der dorsalen Seite des Vorfu\u00dfes zu finden. Arteriolosklerotische Ulzera waren zumeist im mittleren Drittel des lateralen Unterschenkels lokalisiert. Vaskulitische Ulzera schienen zuf\u00e4llig verteilt zu sein und waren deutlich kleiner, h\u00e4ufiger multilokul\u00e4r und bilateral. Das multinomiale logistische Regressionsmodell zeigte eine insgesamt zufriedenstellende Leistung mit einer gesch\u00e4tzten Genauigkeit von 0,68 bei ungesehenen Daten.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Der vorgestellte Algorithmus auf Grundlage der Ulkuslokalisation kann als unterst\u00fctzendes Instrument zur Eingrenzung potenzieller Differenzialdiagnosen und als Hilfestellung f\u00fcr die Einleitung diagnostischer Ma\u00dfnahmen dienen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15192_g","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T08:36:44Z","timestamp":1699605404000},"page":"1339-1350","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Entwicklung eines Lokalisations\u2010basierten Algorithmus zur Vorhersage der \u00c4tiologie von Ulcera 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