{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:03:58Z","timestamp":1779311038826,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eczema herpeticum (EH) is a disseminated skin infection caused by herpes simplex virus in atopic dermatitis (AD) patients. The frequency of EH and the clinical features of EH patients have not yet been investigated in a larger cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sought to investigate the TREATgermany cohort, a multicenter, non\u2010interventional clinical registry of moderately to severely affected AD patients in Germany. Baseline characteristics of patients included between December 2017 and April 2021 were compared between patients without, single, and multiple EH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 893 patients, 195 (21.8%) had at least one EH. Of the 195 patients with EH, 107 had multiple EH (54.9%), representing 12.0% of the total study population. While there were no differences in demographic characteristics, previous treatment, and disease scores at enrollment (itch, IGA, oSCORAD, EASI), patients with EH had more frequent atopic comorbidities and sensitizations to house dust mite, food, and mold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>TREATgermany registry data suggest a high prevalence and recurrence rate of EH, while there appears to be no specific clinical phenotype, besides an increase in allergies, to identify EH patients in the daily routine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15205","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:35:52Z","timestamp":1697078152000},"page":"1490-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High recurrence rate of eczema herpeticum in moderate\/severe atopic dermatitis \u2013TREATgermany registry analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-599X","authenticated-orcid":false,"given":"Stephan","family":"Traidl","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Hannover Medical School  Hannover Germany"},{"name":"Hannover Medical School Cluster of Excellence RESIST (EXC 2155)  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Siegels","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-0458","authenticated-orcid":false,"given":"Lennart","family":"R\u00f6sner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Hannover Medical School  Hannover Germany"},{"name":"Hannover Medical School Cluster of Excellence RESIST (EXC 2155)  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Haufe","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inken","family":"Harder","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Skin Diseases Department of Dermatology and Allergy University Hospital Schleswig\u2010Holstein Campus Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Allergy Center Carl Gustav Carus Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Ertner","sequence":"additional","affiliation":[{"name":"Practice Dr. med. Konstantin Ertner  Nuernberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kleinheinz","sequence":"additional","affiliation":[{"name":"Clinics for Dermatology Elbe Klinikum Buxtehude  Buxtehude Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Sch\u00e4kel","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-8722","authenticated-orcid":false,"given":"Andreas","family":"Wollenberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Augsburg, Augsburg Ludwig Maximilian University  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaak","family":"Effendy","sequence":"additional","affiliation":[{"name":"Department of Dermatology OWL University Hospital of Bielefeld University, Campus Clinic Bielefeld  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Quist","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Helix Medical Ecellence Center Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Asmussen","sequence":"additional","affiliation":[{"name":"Practice Dr. med. Andrea Asmussen Dermatology at Lesum  Bremen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Wildberger","sequence":"additional","affiliation":[{"name":"Practice Dr. med. Julia Wildberger Hautmedizin  Bad Soden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Division of Occupational Dermatology Department of Dermatology Ruprecht\u2010Karls University Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franka","family":"Wiemers","sequence":"additional","affiliation":[{"name":"Practice Dr. med. Franca Wiemers  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens\u2010Joachim","family":"Br\u00fccher","sequence":"additional","affiliation":[{"name":"Practice Dr. med. Jens\u2010Joachim Br\u00fccher Hautambulatorium Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3944-252X","authenticated-orcid":false,"given":"Stephan","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Skin Diseases Department of Dermatology and Allergy University Hospital Schleswig\u2010Holstein Campus Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-0960","authenticated-orcid":false,"given":"Jochen","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Werfel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Hannover Medical School  Hannover Germany"},{"name":"Hannover Medical School Cluster of Excellence RESIST (EXC 2155)  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the TREATgermany Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"issue":"5","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/ddg.14620","article-title":"Inpatient care for skin diseases in Germany: multi\u2010source analysis on the current and future health care needs","volume":"19","author":"Augustin M","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2021_492"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14709"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14853"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00266-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02272E"},{"issue":"1","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ddg.14668","article-title":"JAK\u2010inhibitors in dermatology \u2013 small molecules, big impact? 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