{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:19:37Z","timestamp":1784920777528,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This study analyzed the extent to which the recent introduction of more effective treatments has led to an improvement in real\u2010world psoriasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Patient characteristics and the first\u2010year treatment effectiveness in biologic\u2010naive patients have been analyzed since 2004 until now, irrespective of treatment switches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 2,729 patients were eligible for this analysis. The proportion of female patients increased significantly over the years from 29.9% to 36.2% (p &lt; 0.028), while the number of patients with psoriatic arthritis declined from 36.6% to 30.0% (p &lt; 0.001). Moreover, the duration of psoriatic disease and PASI at the start of the treatment significantly decreased. Last observation carrief forward (LOCF) analysis indicated that PASI 90 response increased from 18.9 to 44.6% at 3 months and from 32.9 to 66.8% at 12 months after treatment started. Similary, the PASI <jats:styled-content>\u2264<\/jats:styled-content> 3 rates increased from 33.2% to 66.0% at 3 months and from 41.9% to 78.9% at 12 months after the treatment started.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The continuous introduction of more efficient biologics has led to significant improvements in patient care and clinical outcomes. Though one out of three to five patients, depending on the endpoint selected, nowadays still does not achieve an entirely satisfactory treatment response (i.e., PASI 90 or PASI \u2264 3).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15213","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T03:24:51Z","timestamp":1698809091000},"page":"1513-1523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evolution of characteristics and biologic treatment effectiveness in patients of the Austrian psoriasis registry from 2004\u20132022"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-7776","authenticated-orcid":false,"given":"Thomas","family":"Graier","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz  Graz 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