{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:43:05Z","timestamp":1768434185101,"version":"3.49.0"},"reference-count":2,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Aktinische Keratosen (AK) sind h\u00e4ufige Hautver\u00e4nderungen bei hellh\u00e4utigen Menschen mit dem Potenzial, in ein kutanes Plattenepithelkarzinom (PEK) \u00fcberzugehen. Beide Erkrankungen k\u00f6nnen mit erheblicher Morbidit\u00e4t verbunden sein und stellen eine gro\u00dfe Krankheitslast insbesondere in der \u00e4lteren Bev\u00f6lkerung dar. Um eine evidenzbasierte Grundlage f\u00fcr die klinische Entscheidungsfindung zu schaffen, wurde die S3\u2010Leitlinie \u201eAktinische Keratose und kutanes Plattenepithelkarzinom\u201c aktualisiert und um die Themen Plattenepithelkarzinom <jats:italic>in situ<\/jats:italic> (Morbus Bowen) und Cheilitis actinica, die Manifestation der AK am Lippenrot, erweitert. Die Leitlinie richtet sich dabei an Dermatologen, Allgemeinmediziner, HNO\u2010\u00c4rzte, Chirurgen, Onkologen, Radiologen und Strahlentherapeuten in Klinik und Praxis sowie an andere medizinische Fachgebiete, politische Entscheidungstr\u00e4ger und Versicherungsgesellschaften, die sich mit der Diagnose und Behandlung von Patienten mit nichtmelanozyt\u00e4rem Hautkrebs befassen. F\u00fcr Patienten und deren Angeh\u00f6rige existiert eine gesonderte Patientenleitlinie. In diesem Teil behandeln wir die Themen Therapie der aktinischen Keratose, Morbus Bowen, Cheilitis actinica, berufsbedingte Erkrankung an AK und PEK sowie Versorgungsstrukturen.<\/jats:p>","DOI":"10.1111\/ddg.15231_g","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:36:55Z","timestamp":1697506615000},"page":"1249-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["S3\u2010Leitlinie \u201cAktinische Keratose und Plattenepithelkarzinom der Haut\u201c \u2013 Update 2023, Teil 1: Therapie der aktinischen Keratose, Morbus Bowen, Cheilitis actinica, berufsbedingte Erkrankung und Versorgungsstrukturen"],"prefix":"10.1111","volume":"21","author":[{"given":"Markus V.","family":"Heppt","sequence":"first","affiliation":[{"name":"Hautklinik Uniklinikum Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen"},{"name":"Comprehensive Cancer Center Europ\u00e4ische Metropolregion Erlangen\u2010N\u00fcrnberg (CCC ER\u2010EMN)  Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Leiter","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Dermatoonkologie Universit\u00e4ts\u2010Hautklinik Eberhard\u2010Karls\u2010Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Steeb","sequence":"additional","affiliation":[{"name":"Hautklinik Uniklinikum Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen"},{"name":"Comprehensive Cancer Center Europ\u00e4ische Metropolregion Erlangen\u2010N\u00fcrnberg (CCC ER\u2010EMN)  Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"Alter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Dermatologie Allergologie Venerologie und Phlebologie Johannes Wesling Klinikum Ruhr\u2010Universit\u00e4t Bochum Campus Minden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Amaral","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Dermatoonkologie Universit\u00e4ts\u2010Hautklinik Eberhard\u2010Karls\u2010Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie Universit\u00e4tsklinikum Carl Gustav Carus Technische Universit\u00e4t Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falk G.","family":"Bechara","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie St. Josef\u2010Hospital Ruhr\u2010Universit\u00e4t Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen C.","family":"Becker","sequence":"additional","affiliation":[{"name":"Translationale Hautkrebsforschung (TSCR) DKTK Essen\/D\u00fcsseldorf Universit\u00e4tsmedizin Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard W.","family":"Breitbart","sequence":"additional","affiliation":[{"name":"Arbeitsgemeinschaft Dermatologische Pr\u00e4vention (ADP) e.V.  Buxtehude"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Breuninger","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Dermatoonkologie Universit\u00e4ts\u2010Hautklinik Eberhard\u2010Karls\u2010Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Sozialmedizin Universit\u00e4t Heidelberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Dirschka","sequence":"additional","affiliation":[{"name":"CentroDerm Wuppertal Heinz\u2010Fangman\u2010Stra\u00dfe 57  Wuppertal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eigentler","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K. Stephan","family":"El Gammal","sequence":"additional","affiliation":[{"name":"Dermatologische Klinik Diakonie Klinikum Bethesda  Freudenberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Felcht","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Dermatochirurgie St. Josefskrankenhaus Heidelberg GmbH  Heidelberg"},{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsmedizin Mannheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Flaig","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie und Allergologie Klinikum der Universit\u00e4t M\u00fcnchen LMU M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Follmann","sequence":"additional","affiliation":[{"name":"Leitlinienprogramm Onkologie Deutsche Krebsgesellschaft e.V.  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Fritz","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Dermatologie Laser und \u00c4sthetische Medizin  Landau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Hautklinik der Universit\u00e4tsmedizin Johannes Gutenberg Universit\u00e4t Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Greinert","sequence":"additional","affiliation":[{"name":"Elbe Kliniken Stade Buxtehude Klinikum Buxtehude"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Gutzmer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Dermatologie Allergologie Venerologie und Phlebologie Johannes Wesling Klinikum Ruhr\u2010Universit\u00e4t Bochum Campus Minden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Hauschild","sequence":"additional","affiliation":[{"name":"Hautklinik Universit\u00e4tsklinikum Schleswig\u2010Holstein  Campus Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Hillen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Venerologie Vivantes Klinikum Neuk\u00f6lln  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Ihrler","sequence":"additional","affiliation":[{"name":"DERMPATH M\u00fcnchen  M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen Malte","family":"John","sequence":"additional","affiliation":[{"name":"Abteilung Dermatologie und Umweltmedizin Universit\u00e4t Osnabr\u00fcck Institut f\u00fcr interdisziplin\u00e4re Dermatologische Pr\u00e4vention und Rehabilitation (iDerm) an der Universit\u00e4t Osnabr\u00fcck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Kofler","sequence":"additional","affiliation":[{"name":"Studienzentrum Operative Dermatologie Universit\u00e4ts\u2010Hautklinik Eberhard\u2010Karls\u2010Universit\u00e4t  T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Koelbl","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Strahlentherapie Universit\u00e4tsklinikum Regensburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Krause\u2010Bergmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Unfall\u2010 und Wiederherstellungschirurgie Orthop\u00e4die Plastische\u2010 \u00c4sthetische\u2010 und Handchirurgie Sektion f\u00fcr Plastische\u2010 \u00c4sthetische\u2010 und Handchirurgie  G\u00fctersloh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Kraywinkel","sequence":"additional","affiliation":[{"name":"Robert Koch\u2010Institut  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Krohn","sequence":"additional","affiliation":[{"name":"Deutsche Gesetzliche Unfallversicherung e.V. (DGUV)  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Langer","sequence":"additional","affiliation":[{"name":"Leitlinienprogramm Onkologie Deutsche Krebsgesellschaft e.V.  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Loquai","sequence":"additional","affiliation":[{"name":"Klinikum Bremen\u2010Ost Klinik f\u00fcr Dermatologie Dermatochirurgie Dermatoonkologie und Allergologie Hautkrebszentrum Bremen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph R.","family":"L\u00f6ser","sequence":"additional","affiliation":[{"name":"Hautklinik Hauttumorzentrum Klinikum Ludwigshafen gGmbH  Ludwigshafen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mohr","sequence":"additional","affiliation":[{"name":"Elbe Kliniken Stade Buxtehude Klinikum Buxtehude"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doroth\u00e9e","family":"Nashan","sequence":"additional","affiliation":[{"name":"Hautklinik Klinikum Dortmund gGmbH  Dortmund"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Nothacker","sequence":"additional","affiliation":[{"name":"Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) Institut f\u00fcr Medizinisches Wissensmanagement, c\/o Philipps Universit\u00e4t Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Pfannenberg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Diagnostische und Interventionelle Radiologie Eberhard\u2010Karls\u2010Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Salavastru","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinderdermatologie Onkologische Dermatologie \u2013 Forschungseinheit Colentina Universit\u00e4tsklinikum \u201eCarol Davila\u201c Universit\u00e4tsmedizin, Bucharest, Bukarest, Rum\u00e4nien"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Schmitz","sequence":"additional","affiliation":[{"name":"CentroDerm Wuppertal Heinz\u2010Fangman\u2010Stra\u00dfe 57  Wuppertal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eggert","family":"Stockfleth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie St. Josef\u2010Hospital Ruhr\u2010Universit\u00e4t Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf\u2010Markus","family":"Szeimies","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie Klinikum Vest GmbH  Recklinghausen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claas","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Dermatologie am Regierungsviertel  Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Voelter\u2010Mahlknecht","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Arbeitsmedizin Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Vordermark","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Strahlentherapie Martin\u2010Luther\u2010Universit\u00e4t Halle\u2010Wittenberg  Halle\/Saale"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weichenthal","sequence":"additional","affiliation":[{"name":"Hautklinik Universit\u00e4tsklinikum Schleswig\u2010Holstein  Campus Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Welzel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie Universit\u00e4tsklinikum Augsburg Medizincampus S\u00fcd  Augsburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wermker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Mund\u2010 Kiefer\u2010 und Gesichtschirurgie Plastische und \u00c4sthetische Operationen  Klinikum Osnabr\u00fcck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals\u2010 Nasen\u2010 und Ohrenheilkunde Universit\u00e4tsklinikum Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Garbe","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Dermatoonkologie Universit\u00e4ts\u2010Hautklinik Eberhard\u2010Karls\u2010Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Berking","sequence":"additional","affiliation":[{"name":"Hautklinik Uniklinikum Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen"},{"name":"Comprehensive Cancer Center Europ\u00e4ische Metropolregion Erlangen\u2010N\u00fcrnberg (CCC ER\u2010EMN)  Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/ddg.14048","article-title":"S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma \u2010 short version, part 1: diagnosis, interventions for actinic keratoses, care structures and quality\u2010of\u2010care indicators","volume":"18","author":"Heppt MV","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"issue":"4","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/ddg.14072","article-title":"S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) \u2010 short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow\u2010up, prevention and occupational disease","volume":"18","author":"Leiter U","year":"2020","journal-title":"J Dtsch Dermatol Ges"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15231_g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:36:58Z","timestamp":1697506618000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15231_g"}},"subtitle":["S3 guideline \u201eactinic keratosis and cutaneous squamous cell carcinoma\u201c\u2013 update 2023, part 1: treatment of actinic keratosis, actinic cheilitis, cutaneous squamous cell carcinoma in situ (Bowen's disease), occupational disease and structures of care"],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":2,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/ddg.15231_g"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15231_g","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}