{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:33:23Z","timestamp":1784349203436,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few prospective studies exist with an evaluation of a dose\u2010response relationship between use of some photosensitizing antihypertensive medications and skin cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and Methods<\/jats:title><jats:p>We used prospective data from the <jats:italic>Women's Health Initiative Observational Study<\/jats:italic> to investigate the association between antihypertensive use and risk of non\u2010melanoma skin cancer (NMSC) and melanoma in postmenopausal women aged 50\u201379\u00a0years at baseline (n\u00a0 = \u00a064,918). Multivariable Cox proportional hazards regression models were used and hazard ratios (HRs) and 95 confidence intervals (CIs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>8,777 NMSC and 1,227 melanoma cases were observed. Use of antihypertensives (HR [95% CI]: 1.12 [1.07\u20131.18]), ACE inhibitors (1.09 [1.01\u20131.18]), calcium channel blockers (1.13 [1.05\u20131.22]), diuretics (1.20 [1.12\u20131.27]), loop diuretics (1.17 [1.07\u20131.28]), and thiazides (1.17 [1.03\u20131.33]) were each associated with higher NMSC risk. NMSC risk linearly increased with use of multiple antihypertensives (p\u2010trend\u00a0 = \u00a00.02) and with longer duration of use (p\u2010trend\u00a0&lt;\u00a00.01). Antihypertensives (1.15 [1.00\u20131.31]), angiotensin\u2010II receptor blockers (1.82 [1.05\u20133.15]), and diuretics (1.34 [1.13\u20131.59]) were each associated with elevated melanoma risk. Effect modification by solar radiation exposure was found between antihypertensive use and incidence of melanoma (p\u2010interaction\u00a0 = \u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of antihypertensives overall, and several individual classes thereof, were associated with higher incidence of NMSC and melanoma with dose\u2010response relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15281","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T13:10:25Z","timestamp":1707743425000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Photosensitizing antihypertensive medication and risk of skin cancer among postmenopausal women"],"prefix":"10.1111","volume":"22","author":[{"given":"Alexander","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine Northwestern University  Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Warren Alpert Medical School Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science University of California San Diego, CA  La Jolla USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Indiana University Richard M. 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