{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:52:29Z","timestamp":1787759549323,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Over the past two decades, there has been a rise in the incidence of syphilis, particularly among men who have sex with men (MSM). This has sparked interest in studying the prophylactic use of doxycycline to prevent syphilis and other sexually transmitted infections (STIs), commonly referred to as Doxycycline Pre\u2010 or Post\u2010Exposure Prophylaxis (Doxy\u2010PrEP, Doxy\u2010PEP). At the same time, demand from potential users for this preventive measure is increasing.<\/jats:p><jats:p>Several randomized controlled trials have demonstrated that the prophylactic use of doxycycline in MSM and trans women using HIV pre\u2010exposure prophylaxis (HIV\u2010PrEP) or living with an HIV infection effectively reduces the risk of syphilis and chlamydia infections. At present, however, unresolved questions remain, particularly regarding implications of a broad implementation of prophylactic doxycycline to prevent STIs on tetracycline and other antimicrobial resistance in bacterial STIs, non\u2010STI\u2010related bacterial pathogens, and the microbiome.<\/jats:p><jats:p>In response to the increasing demand and the challenge of balancing effectiveness, safety, and the risk of promoting antibiotic resistance, the German STI Society (DSTIG) has issued a position statement, providing specific recommendations regarding potential indications, criteria, and occasions for the use of doxycycline in STI prevention. These recommendations are based on current evidence and expert opinion.<\/jats:p>","DOI":"10.1111\/ddg.15282","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:05:14Z","timestamp":1703131514000},"page":"466-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Position statement of the German STI Society on the prophylactic use of doxycycline to prevent STIs (Doxy\u2010PEP, Doxy\u2010PrEP)"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-1392","authenticated-orcid":false,"given":"Ricardo Niklas","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Division of Evidence Based Medicine (dEBM) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel Jeremias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Sigma Research Department of Public Health Environments and Society London School of Hygiene and Tropical Medicine  London UK"},{"name":"Department of Medicine and Health Policy Deutsche AIDS\u2010Hilfe  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Potthoff","sequence":"additional","affiliation":[{"name":"Interdisciplinary Immunological Outpatient Clinic Clinic for Dermatology Venereology and Allergology Ruhr University Bochum  Bochum Germany"},{"name":"WIR \u2013 Walk In Ruhr \u2013 Centre for Sexual Health and Medicine  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Spornraft\u2010Ragaller","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert Hermann","family":"Brockmeyer","sequence":"additional","affiliation":[{"name":"German STI Society\/Deutsche STI\u2010Gesellschaft (DSTIG) Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the German STI Society (DSTIG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009529"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2020.20392"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH14003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13776"},{"key":"e_1_2_10_6_1","article-title":"Interventions for rosacea","volume":"2015","author":"Zuuren EJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_7_1","first-page":"516","article-title":"S2k guidelines for the treatment of pemphigus vulgaris\/foliaceus and bullous pemphigoid: 2019 update","volume":"18","author":"Schmidt E","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1919-2660"},{"key":"e_1_2_10_9_1","unstructured":"Deutsche STI Gesellschaft(federf\u00fchrend).Infektionen mit Chlamydia trachomatis. 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