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Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin\u00a0A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty\u2010six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91% (n\u00a0=\u00a082\/90) and 89% (n\u00a0=\u00a0525\/580) of patients respectively, followed by intense pulsed light (89%, n\u00a0=\u00a097\/109 partial response), cyclosporine ophthalmic emulsion (87% n\u00a0=\u00a040\/46), and lid hygiene (65%, n\u00a0=\u00a067\/105). Combination treatments achieved a complete or partial response in 90% (n\u00a0=\u00a069\/77). Results suggest that topical antimicrobials, oral antibiotics, intense pulsed light. and cyclosporine were the most efficacious single modality treatments.<\/jats:p>","DOI":"10.1111\/ddg.15290","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T12:19:25Z","timestamp":1705753165000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of ocular rosacea: a systematic review"],"prefix":"10.1111","volume":"22","author":[{"given":"Shani","family":"Avraham","sequence":"first","affiliation":[{"name":"Foresee Eyecare  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Khaslavsky","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-3783","authenticated-orcid":false,"given":"Nadia","family":"Kashetsky","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Memorial University of Newfoundland  St. John's NL Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-1883","authenticated-orcid":false,"given":"Samantha Y.","family":"Starkey","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-8669","authenticated-orcid":false,"given":"Kirill","family":"Zaslavsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3369","authenticated-orcid":false,"given":"Joseph M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver BC Canada"},{"name":"BC Children's Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-9413","authenticated-orcid":false,"given":"Ilya","family":"Mukovozov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"issue":"1775","key":"e_1_2_7_3_1","first-page":"27","article-title":"Improving the management of rosacea in primary care","volume":"258","author":"Tidman MJ","year":"2014","journal-title":"Practitioner"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"544","article-title":"Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline","volume":"8","author":"Arman A","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.07.005"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"112","article-title":"The ocular manifestations of rosacea","volume":"68","author":"Tanzi EL","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492012000500016"},{"key":"e_1_2_7_8_1","first-page":"372","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page MJ","year":"2021","journal-title":"BMJ"},{"key":"e_1_2_7_9_1","unstructured":"PhillipsB BallC SackettD et\u00a0al.Oxford Centre for Evidence\u2010based Medicine Levels of Evidence.2009. 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