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However, literature specific to skin microbiome and skin cancer remain heterogenous and scattered.<\/jats:p><jats:p>A systematic review was performed to identify the existing literature and its usefulness in providing microbiome\u2010based biomarkers. A search of the databases (PubMed, Medline, EMBASE, GoogleScholar) was conducted from June to July 2022 in accordance with the PRISMA guidelines.<\/jats:p><jats:p>A total of 1,543 articles were identified, of which 16 were selected for inclusion in the review (11 articles on cancer of the keratinocytes and 5 articles on melanoma). Increased <jats:italic>Staphylococcus (S.) aureus<\/jats:italic> prevalence with decline in commensal organisms is seen in squamous cell carcinoma (SCC) and actinic keratosis (AK), compared to healthy skin. While the microbiome of melanoma appears to be distinct from healthy skin, limited data is available to draw meaningful conclusions.<\/jats:p><jats:p>Our review summarizes the current evidence on the microbiome of keratinocyte skin cancers and melanoma. The study establishes that the microbiome of these cancers is altered from healthy skin and that this dysbiosis involves both pathogenic and commensal organisms.<\/jats:p>","DOI":"10.1111\/ddg.15294","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T12:19:27Z","timestamp":1705753167000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The cutaneous microbiome in skin cancer \u2013 A systematic review"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-9907","authenticated-orcid":false,"given":"Ruojun","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Dermatology Singapore General Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShengYang Bertrand","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Singapore General 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