{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:51:17Z","timestamp":1790718677653,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Onychomycosis is common and important to distinguish from other nail diseases. Rapid and accurate diagnosis is necessary for optimal patient treatment and outcome. Non\u2010invasive diagnostic tools have increasing potential for nail diseases including onychomycosis. This study evaluated line\u2010field confocal optical coherence tomography (LC\u2010OCT) as a rapid non\u2010invasive tool for diagnosing onychomycosis as compared to confocal laser scanning microscopy (CLSM), optical coherence tomography (OCT), and conventional methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In this prospective study 86 patients with clinically suspected onychomycosis and 14 controls were examined using LC\u2010OCT, OCT, and CLSM. KOH\u2010preparation, fungal culture, PCR, and histopathology were used as comparative conventional methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LC\u2010OCT had the highest sensitivity and negative predictive value of all methods used, closely followed by PCR and OCT. Specificity and positive predictive value of LC\u2010OCT were as high as with CLSM, while OCT scored much lower. The gold standard technique, fungal culture, showed the lowest sensitivity and negative predictive value. Only PCR and culture allowed species differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LC\u2010OCT enables quick and non\u2010invasive detection of onychomycosis, with advantages over CLSM and OCT, and similar diagnostic accuracy to PCR but lacking species differentiation. For accurate nail examination, LC\u2010OCT requires well\u2010trained and experienced operators.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15310","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T06:41:36Z","timestamp":1706337696000},"page":"367-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Line\u2010field confocal optical coherence tomography, a novel non\u2010invasive tool for the diagnosis of onychomycosis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8014-4152","authenticated-orcid":false,"given":"Quirine Louise","family":"Eijkenboom","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabia","family":"Daxenberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Gust","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-0526","authenticated-orcid":false,"given":"Anne","family":"Guertler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Steckmeier","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University 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