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The most common subtype of CPG is chronic nodular prurigo (CNPG, also called prurigo nodularis).<\/jats:p><jats:p>In addition to the clinical features of CPG and the burden of disease, this CME article provides an overview of the significant advances in understanding the pathophysiology, including the associated therapeutic options for CPG. Dupilumab is the first approved therapy for moderate and severe CNPG to date from the European Medicines Agency (EMA) and the US Food &amp; Drug Administration (FDA). It also highlights other agents currently being studied in Phase II and Phase III clinical, randomized, placebo\u2010controlled trials. 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