{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:11:52Z","timestamp":1788549112798,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Mycosis fungoides (MF), the most common primary cutaneous T\u2010cell lymphoma, is characterized by a variable clinical course, presenting either as indolent disease or showing fatal progression due to extracutaneous involvement. Importantly, the lack of prognostic models and predominantly palliative therapy settings hamper patient care. Here, we aimed to define survival rates, disease prediction accuracy, and treatment impact in MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Hundred\u2010forty MF patients were assessed retrospectively. Prognosis and disease progression\/survival were analyzed using univariate Cox proportional hazards regression model and Kaplan\u2010Meier estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin tumors were linked to shorter progression\u2010free, overall survival and a 3.48 increased risk for disease progression when compared to erythroderma. The <jats:italic>Cutaneous Lymphoma International Prognostic Index<\/jats:italic> identified patients at risk in early\u2010stage disease only. Moreover, expression of Ki\u201067 &gt;20%, CD30 &gt;10%, CD20<jats:sup>+<\/jats:sup>, and CD7<jats:sup>\u2013<\/jats:sup> were associated with a significantly worse outcome independent of disease stage. Only single\u2010agent interferon\u2010\u03b1 and phototherapy combined with interferon\u2010\u03b1 or retinoids\/bexarotene achieved long\u2010term disease control in MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support predictive validity of prognostic factors and models in MF and identified further potential parameters associated with poor survival. Prospective studies on prognostic indices across disease stages and treatment modalities are needed to predict and improve survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15331","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T07:25:07Z","timestamp":1709709907000},"page":"532-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of mortality, prognostic parameters, and treatment efficacy in mycosis fungoides"],"prefix":"10.1111","volume":"22","author":[{"given":"Stefanie","family":"Porkert","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Viena Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Griss","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Viena 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