{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:54:21Z","timestamp":1777658061050,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Atopic dermatitis (AD) is the most common skin disease in infants and children with a prevalence of 10% in the first two years of life. In this age group up to 15% are severely affected. \u201cChildren are not little adults\u201d \u2010 this applies in particular to infants with severe atopic dermatitis. Age\u2010specific clinical aspects (psychosocial, neurocognitive, morphological) of the disease require an adjusted disease management. Considering recent approval of systemic treatment options, early identification of infants and children with severe and early persistent disease is of particular importance also in view of possible prevention of atopic comorbidity. As several inborn errors of immunity (IEI) share features of the atopic phenotype, it is essential for clinicians to distinguish signs of immunodeficiency from severe AD. Here, we describe a practical approach on the basis of clinical history and key dermatological and laboratory findings. Furthermore, this paper is aimed at providing an update on general management of severe AD in early infancy, including recommendations for systemic treatment.<\/jats:p>","DOI":"10.1111\/ddg.15344","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:51:18Z","timestamp":1709808678000},"page":"350-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severe atopic dermatitis in early infancy: characteristics, challenges and new perspectives in clinical practice"],"prefix":"10.1111","volume":"22","author":[{"given":"Andreas Benedikt","family":"Weins","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Hospital Augsburg  Augsburg Germany"},{"name":"KIDZ SKIN | Practice for Pediatric Dermatology  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Kerzel","sequence":"additional","affiliation":[{"name":"Barmherzige Br\u00fcder Hospital Department of Pediatrics Section for Pediatric Pneumonology and Allergology  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Schnopp","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology am Biederstein Technical University Munich  Munich Germany"},{"name":"Practice Burgstra\u00dfe  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"3","article-title":"Allergic diseases in children and adolescents in Germany. 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