{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:49Z","timestamp":1787014069979,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with chronic inflammatory skin diseases often suffer from sleep disturbances. However, objective data on sleep architecture, especially to evaluate potential overall influences under therapy, are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Pilot study on sleep quality changes including psoriasis and atopic dermatitis patients before and 2\u00a0weeks after intensive topical treatment. In addition to disease activity rating, patient\u2010rated outcomes for itch severity and sleep quality and polygraphy was performed before and after topical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>14 psoriasis, eleven atopic dermatitis patients (10 female, 15 male) with a mean age of 49 years were included. Disease activity scores (EASI and PASI) were significantly reduced with topical therapy after 2\u00a0weeks (p\u00a0&lt;\u00a00.001). Pruritus intensity (NRS) showed a significant influence on deep sleep, which resolved after therapy. Insomnia severity significantly decreased (r\u00a0&gt;\u00a00.50, p\u00a0&lt;\u00a00.05) and daytime sleepiness showed a significant reduction in 40% of patients. N3 (deep sleep) and REM sleep significantly improved, showing a strong effect (r\u00a0&gt;\u00a00.50). The apnea\u2010hypopnea index decreased in one of four patients independent of the individual BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Through polygraphy, we demonstrated impaired sleep patterns in psoriasis and atopic dermatitis patients with itch as a relevant factor and beyond that, rapid sleep improvement under 2\u00a0weeks of topical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15373","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T09:08:36Z","timestamp":1713431316000},"page":"655-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Burden of impaired sleep and its improvement through topical treatment in psoriasis and atopic dermatitis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-2216","authenticated-orcid":false,"given":"Caroline","family":"Mann","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dreher","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology Department of Internal Medicine I University Medical Center of the Johannes Gutenberg University  Mainz Germany"},{"name":"University Center for Autoimmunity University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Niklas","family":"Rothschmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Staubach","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University  Mainz Germany"},{"name":"University Center for Autoimmunity University Medical Center of the Johannes Gutenberg University  Mainz 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