{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:46:17Z","timestamp":1777617977236,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The gastrointestinal tract may contribute to the regulation of systemic inflammation and skin diseases due to the balance between the pathogenic, opportunistic, and beneficial bacterial species it contains. External supplementation of beneficial bacteria, besides its known positive effect in the treatment of digestive system diseases, also has different favorable effects such as accelerated wound healing, suppression of inflammation, lower infection risk, and reduced antibiotic requirement. It has been reported that oral use of probiotics may be effective in the treatment of skin diseases such as acne, psoriasis, and atopic dermatitis. Furthermore, topical administration of probiotics may create a positive bacterial balance, eliminate pathological conditions, and thus have a favorable impact on the management of skin diseases. Interest in the effect of the skin microbiome and topical probiotics in the treatment of skin diseases has increased recently. Herein, 21 clinical studies and a case report in the PubMed database on the use of topical probiotics in dermatological diseases were evaluated.<\/jats:p>","DOI":"10.1111\/ddg.15465","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:36:10Z","timestamp":1724290570000},"page":"1195-1204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the therapeutic potential of topical probiotics in dermatological diseases: a comprehensive review of clinical studies"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-5583","authenticated-orcid":false,"given":"Funda","family":"Tamer","sequence":"first","affiliation":[{"name":"Department of Dermatology Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Kekilli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gazi University School of Medicine Department of Gastroenterology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030557"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00476-7"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14032"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz7015"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061420"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071303"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100521"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071486"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14971"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-008-0179-y"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15120"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llac138"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8071026"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-021-04789-2"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S135529"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.2.150"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00051.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15143123"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13060"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15657"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15510"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15133055"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13451"},{"key":"e_1_2_13_26_1","doi-asserted-by":"crossref","unstructured":"Arga\u00f1araz AybarJN Ortiz MayorS OleaL et\u00a0al.Topical administration ofLactiplantibacillus plantarumaccelerates the healing of chronic diabetic foot ulcers through modifications of infection angiogenesis macrophage phenotype and neutrophil response.Microorganisms.2022;10:634.","DOI":"10.3390\/microorganisms10030634"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-2111-0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02793.x"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2008.00577.x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78281-7"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060771"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-017-1139-9"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02508.x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64705-x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbe1501006"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12116"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13949"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.821696"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3255044062"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201023666220411090301"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101436"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T04:29:04Z","timestamp":1744518544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/ddg.15465"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15465","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"2023-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}