{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:05:15Z","timestamp":1775556315299,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Complicated erysipelas, cellulitis, and necrotizing soft tissue infections belong to the spectrum of bacterial infections affecting the skin and underlying soft tissues. Their frequency as well as risk of recurrence and complicated disease course pose a significant health burden. The latter is further impacted by global travel activity, associated variations in the prevalence of microbes, the emergence of multi\u2010resistant bacteria, demographically driven aging with an increase in critical comorbidities, immunosuppressive therapies, and excessive (including non\u2010medical) use of antibiotics.<\/jats:p><jats:p>Against this background, early and accurate diagnosis and promptly initiated therapeutic measures are major determinants in prognosis and clinical outcome. Diagnostic evaluation involves clinical, laboratory, microbiological, and radiographic findings, which are assessed in the context of patient\u2010specific risk factors and comorbidities. First and foremost, given the indication, exploratory incisions of lesional tissue should be performed, allowing rapid assessment of the extent of tissue necrosis and providing guidance on the scope and extent of further (surgical and non\u2010surgical) treatment modalities. Thus, delayed or inadequate interventions can be avoided, which reduces the duration of treatment, health expenses, the risk of recurrent hospitalizations, and mortality rates.<\/jats:p>","DOI":"10.1111\/ddg.15493","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T16:51:14Z","timestamp":1741625474000},"page":"357-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Complicated and deep bacterial skin and soft tissue infections"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-8140","authenticated-orcid":false,"given":"Christine","family":"Prodinger","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-0509","authenticated-orcid":false,"given":"Arno","family":"Lechner","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Hygiene University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Hintersteininger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Marco","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Hygiene University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Mei\u00dfnitzer","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-6917","authenticated-orcid":false,"given":"Damian","family":"Meyersburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-9170","authenticated-orcid":false,"given":"Johann W.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-0374","authenticated-orcid":false,"given":"Martin","family":"Laimer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Calculated initial parenteral treatment of bacterial infections: Skin and soft tissue infections","volume":"8","author":"Sunderk\u00f6tter C","year":"2020","journal-title":"GMS Infect Dis"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/ddg.14816_g","article-title":"S1\u2010Leitlinie: Differenzialdiagnose akuter und chronischer R\u00f6tungen der Unterschenkel","volume":"20","author":"Zidane M","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.054"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-022-01087-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-016-0097-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3181cb8cea"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.2018.1506673"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106637"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-023-08229-w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2023.109876"},{"key":"e_1_2_9_12_1","unstructured":"Physicians RCo.National Early Warning Score (NEWS) 2: Standardising the assessment of acute\u2010illness severity in the NHS. Updated report of a working party. Available from:https:\/\/www.rcplondon.ac.uk\/projects\/outputs\/national\u2010early\u2010warning\u2010score\u2010news\u20102[Last accessed December 20 2023]."},{"key":"e_1_2_9_13_1","article-title":"Screening auf Sepsis in der Notfallmedizin \u2013 qSOFA ist uns nicht genug","author":"Bauer W","year":"2023","journal-title":"Notf Rett Med"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133583"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000129486.35458.7D"},{"issue":"3","key":"e_1_2_9_16_1","first-page":"iii35","article-title":"Complicated skin and soft tissue infection","volume":"65","author":"Dryden MS","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000636"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2018.11.013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.01.028"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2020.05.004"},{"key":"e_1_2_9_21_1","unstructured":"FuchsR FuchsK.Antibiotika\u2010Vertriebsmengen in der Veterin\u00e4rmedizin. Available from:https:\/\/www.ages.at\/tier\/tierarzneimittel\u2010hormone\/antibiotika\u2010vertriebsmengen\u2010in\u2010der\u2010veterinaermedizin\u20102021[Last accessed December 18 2023]."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.6.704"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.12.010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00318-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.07.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S413126"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2021.09.015"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI149523"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30807-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0316-z"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13790_g"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2021.115389"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2018.07.008"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.09.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2022.115722"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03560-9"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.10.033"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122329"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-021-03875-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1086\/526444"},{"key":"e_1_2_9_41_1","first-page":"137","article-title":"Corticosteroid Therapy in Combination with Antibiotics for Erysipelas","volume":"20","author":"Solomon M","year":"2018","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_9_42_1","article-title":"Corticosteroids for periorbital and orbital cellulitis","volume":"4","author":"Kornelsen E","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_43_1","first-page":"348","article-title":"[Should NSAID\/corticoids be considered when treating erysipelas?]","volume":"128","author":"Jaussaud R","year":"2001","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_9_44_1","first-page":"177","article-title":"Rapid resolution of cellulitis in patients managed with combination antibiotic and anti\u2010inflammatory therapy","volume":"75","author":"Dall L","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu296"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit594"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw871"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4786-0"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.697938"},{"key":"e_1_2_9_50_1","first-page":"24","article-title":"Consensus conference","volume":"47","author":"Mathieu D","year":"2017","journal-title":"Medicine"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-023-00490-y"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00006"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.03.025"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2017.01.007"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000434"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000440"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.04.013"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2021.1828865"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268818003291"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.10.032"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-019-0286-6"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03561-7"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917197"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.12.044"},{"key":"e_1_2_9_65_1","article-title":"Interventions for the prevention of recurrent erysipelas and cellulitis","volume":"6","author":"Dalal A","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_66_1","first-page":"12","article-title":"New Antibiotics for Staphylococcus aureus Infection: An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti\u2010Infective Therapy (SITA)","author":"Esposito S","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"e_1_2_9_67_1","first-page":"1","volume-title":"DGIM Innere Medizin: herausgegeben von Hendrik Lehnert","author":"Kern JM","year":"2020"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2014.089"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T16:52:20Z","timestamp":1741625540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/ddg.15493"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15493","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2023-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}