{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:36:04Z","timestamp":1757612164248,"version":"3.44.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of allergies to beta\u2010lactam antibiotics is significantly overestimated based on anamnestic data \u2010 with significant medical and economic consequences. The aim of the study was to determine the frequency of immediate and delayed type reactions to beta\u2010lactam antibiotics in order to optimize diagnostics and therapy. One focus was on the time interval between reaction and testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methodology<\/jats:title><jats:p>Anamnestic and diagnostic data of patients with suspected allergy to beta\u2010lactam antibiotics who were examined in our department between 2020 and 2022 were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>27\/116 (23%) patients reacted in the skin tests. Type I sensitizations were detected in 4\/35 patients (11%), type IV sensitizations in 23\/83 (28%). In the case of negative\u00a0<jats:italic>in vitro diagnostics<\/jats:italic>\u00a0and skin testing, inpatient provocation tests were performed in 41\/89 (46%). Type I allergies were confirmed in two of the 13 provoked patients (15%) with immediate type reactions, type IV allergies in three of 29 (10%) with delayed type reactions. The results were clearly related to the time interval after reaction. At less than one year, 19% (22\/116) reacted, whereas only 4% (5\/116) reacted at more than one year (for type I reaction 9% vs. 3%; for type IV reaction 23% vs. 5%).\u00a0<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The importance of the time interval between clinical event and allergological testing supports the guideline recommendation for skin testing within one year. Guideline recommendations on the diagnostic procedure for unclear reactions that occurred in the more distant past are desirable in order to rule out allergies to beta\u2010lactam antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15506","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T15:08:35Z","timestamp":1726585715000},"page":"1383-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequency and diagnostic findings of type I and type IV reactions to beta\u2010lactam antibiotics \u2013 significance of the time interval between clinical reaction and skin testing"],"prefix":"10.1111","volume":"22","author":[{"given":"Kimberley","family":"Farmer","sequence":"first","affiliation":[{"name":"Allergology and Immunology Department of Dermatology Venereology, and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsbeth","family":"Oestmann","sequence":"additional","affiliation":[{"name":"Allergology and Immunology Department of Dermatology Venereology, and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1245","authenticated-orcid":false,"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Allergology and Immunology Department of Dermatology Venereology, and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15007-020-2589-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1807761"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02310"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15007-019-1876-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13848"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12774"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14122"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02422E"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.995"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2021.100602"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70439-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12390"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T07:10:30Z","timestamp":1756969830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/ddg.15506"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15506","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"type":"print","value":"1610-0379"},{"type":"electronic","value":"1610-0387"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"assertion":[{"value":"2024-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}