{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:21:09Z","timestamp":1788970869041,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interferon\u2010alpha is an important therapeutic option for the treatment of the cutaneous T\u2010cell lymphomas (CTCL). Since the approved recombinant interferon\u2010\u03b1\u20102a\u00a0(IFN\u2010\u03b12a) has no longer been produced since\u00a0January 2020, pegylated interferon\u2010\u03b12a (pegIFN\u2010\u03b12a) can be used as an alternative treatment, even though it is not approved for the treatment of CTCL. The aim of this multicentre study was to generate comprehensive data on the efficacy and tolerability of pegIFN\u2010\u03b12a in the treatment of CTCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A multicenter retrospective study was conducted with 70 patients with CTCL from twelve German skin centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 70 patients were included in the study, with 57.2% male and a mean age of 58.8 \u00b1\u00a014.9 years. Mycosis fungoides was present in 71.4% of cases and S\u00e9zary Syndrome in 28.6%. An overall response rate of 55.2% was observed with pegIFN\u03b1\u20102a therapy. In 50% of cases, therapy was discontinued after 63.6 \u00b1\u00a033.5 weeks. The most common reason for discontinuation was adverse events, which occurred in 68.6% of cases and which were classified as severe in 29.2%. Blood count changes, fatigue and liver toxicity occurred most frequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analysis provides comprehensive data on the efficacy and tolerability of pegIFN\u03b1\u20102a therapy in patients with CTCL. In terms of response rates and side effect profile, pegIFN\u03b1\u20102a appears to be comparable to IFN\u2010\u03b12a therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15511","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:30:29Z","timestamp":1727933429000},"page":"1489-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pegylated interferon\u2010\u03b12a in cutaneous T\u2010cell lymphoma \u2013 a multicenter retrospective data analysis with 70 patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Inga","family":"Hansen\u2010Abeck","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Hamburg\u2010Eppendorf  Hamburg 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