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SJS and TEN are nowadays considered as variants of one disease entity with varying degrees of severity called epidermal necrolysis (EN). EN is associated with high morbidity and mortality and constitutes a major disease burden for affected patients. The guideline \u201cDiagnosis and treatment of epidermal necrolysis (Stevens\u2010Johnson syndrome and toxic epidermal necrolysis)\u201d was developed under systematic consideration of existing scientific literature and in a formal consensus process according to regulations issued by the Association of Scientific Medical Societies in Germany (AWMF) to establish an evidence\u2010based framework to support clinical decision\u2010making. The interdisciplinary guideline commission consisted of representatives from various specialist societies and of patient representatives. The guideline is aimed at specialists in the fields of dermatology, ophthalmology, plastic surgery, intensive care, and pediatrics in hospitals and offices, as well as other medical specialties involved in the diagnosis and treatment of EN. The guideline is also aimed at patients, their relatives, insurance funds, and policymakers. The second part is concerned with the topics of supportive therapy in the acute phase of EN and outpatient follow\u2010up treatment.<\/jats:p>","DOI":"10.1111\/ddg.15516","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:27:11Z","timestamp":1729160831000},"page":"1576-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens\u2010Johnson syndrome and toxic epidermal necrolysis) \u2013 Part 2: Supportive therapy of EN in the acute and post\u2010acute stages"],"prefix":"10.1111","volume":"22","author":[{"given":"Maren","family":"Paulmann","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Center for the Documentation of Severe Skin Reactions (dZh) University Medical Center Freiburg  Freiburg 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