{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:36:18Z","timestamp":1788280578451,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Port\u2010wine birthmarks (PWB) are common vascular malformations in infants. Despite various laser and light\u2010based treatments, comparative data on their effectiveness is limited. This study compares different treatments for PWB using a systematic review and network meta\u2010analysis (NMA). We searched for randomized controlled trials (RCTs) and ongoing studies up to November 2023: Primary outcomes were patient satisfaction, investigator\u2010assessed reduction in redness, and long\u2010term adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias\u00a02 Tool.<\/jats:p><jats:p>We identified 27 RCTs for qualitative analysis and twelve RCTs for the NMA, covering 1033\u00a0observations, 19 treatments, and three sub\u2010networks. Seven studies reported on patient satisfaction. Hemoporfin\u2010mediated photodynamic therapy was more effective in lesion clearance than PDL but had the highest risk of AEs. The 755\u00a0nm alexandrite laser and the combination of 595\u00a0nm PDL + 1064\u00a0nm Nd:YAG also showed high AE risks. Treatment discontinuation rates due to AEs did not significantly differ. Most studies had unclear bias risks, mostly owing to insufficient reporting.<\/jats:p><jats:p>This study is the first NMA comparing laser\u2010 and light\u2010based therapies for PWB. Further well\u2010designed studies are warranted to determine optimal methods and patient\u2010influencing factors for individualized treatments.<\/jats:p>","DOI":"10.1111\/ddg.15612","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T04:56:16Z","timestamp":1734065776000},"page":"293-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Laser and light\u2010based treatments for port\u2010wine birthmarks \u2013 a systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-6390","authenticated-orcid":false,"given":"Lynhda","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Laser and Aesthetic Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg 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