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It is not possible to differentiate with certainty between pathogens on the basis of clinical characteristics alone. However, empirical antibiotic therapy is often initiated in clinical practice. The aim of this clinical practice guideline is to promote an evidence\u2010based syndrome\u2010orientated approach to the management of male adolescents and adults with symptoms of urethritis.\n                  <\/jats:p>\n                  <jats:p>\n                    Besides recommendations for the diagnosis, classification and choice of treatment, this guideline provides recommendations for the indication to empirically treat patients with penile urethritis. A novel feature compared to existing, pathogen\u2010specific guidelines is the inclusion of a flowchart for the syndrome\u2010orientated practical management. For suspected gonococcal urethritis requiring empirical treatment, ceftriaxone is recommended. 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This guideline also includes detailed recommendations on differential diagnosis, pathogen\u2010specific treatments and specific situations, as well as patient counselling and follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/ddg.15617","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T09:05:16Z","timestamp":1737104716000},"page":"254-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["German evidence\u2010 and consensus\u2010based guideline on the management of penile urethritis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-1392","authenticated-orcid":false,"given":"Ricardo Niklas","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Division of Evidence\u2010Based Medicine in Dermatology (dEBM) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate 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