{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:59:58Z","timestamp":1789984798196,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and Objectives<\/jats:bold>\n                    : Generalized pustular psoriasis (GPP) is a rare, chronic, potentially life\u2010threatening skin disease. We aimed to establish criteria to accurately approximate GPP prevalence in Germany.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : A retrospective analysis of the WIG2 health claims database (1\/1\/2016\u201331\/12\/2020) was conducted. Patients aged \u2265\u00a012 years continuously enrolled in their statutory health insurance with one inpatient or confirmed outpatient diagnosis code for GPP (International Classification of Diseases, 10\n                    <jats:sup>th<\/jats:sup>\n                    Revision [ICD\u201010] L40.1) were included. Scenarios with increasingly strict criteria were used to identify the GPP population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : From 2016\u20132020, 5,236 potential GPP cases were identified based on a recorded GPP diagnosis. The scenario of \u2265\u00a01 GPP diagnosis yielded the highest prevalence (336\u2013390 patients\/million) followed by &gt;\u00a01 GPP diagnosis in \u2265\u00a02 quarters (189\u2013288 patients\/million); scenarios resulting in the lowest prevalence were diagnosis in \u2265\u00a02 quarters AND two independent diagnoses (17\u201328\/million) and diagnosis in \u2265\u00a02 quarters AND two independent diagnoses or diagnosis by a specialist AND potential flare (58\u201361 patients\/million).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : This study suggests that diagnosis in \u2265\u00a02 quarters by a specialist or two independent physicians may be the most clinically robust and reliable criteria for estimating GPP prevalence; therefore, 50\u2013100 patients\/million may represent a reasonable prevalence estimate range for Germany.\n                  <\/jats:p>","DOI":"10.1111\/ddg.15633","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:01:39Z","timestamp":1741726899000},"page":"589-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology of generalized pustular psoriasis in Germany: Analyzing factors influencing prevalence estimates health insurance data"],"prefix":"10.1111","volume":"23","author":[{"given":"Michael","family":"Schultze","sequence":"first","affiliation":[{"name":"ZEG \u2013 Berlin Center for Epidemiology and Health Research  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Kossack","sequence":"additional","affiliation":[{"name":"WIG2 \u2013 Scientific Institute for Health Economics and Health System Research  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-4907","authenticated-orcid":false,"given":"Christian","family":"Kromer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology, and Allergology, University Medical Center, G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH  Ingelheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Kolb","sequence":"additional","affiliation":[{"name":"ZEG \u2013 Berlin Center for Epidemiology and Health Research  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21588"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4951"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2116003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14386"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-023-00779-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14523"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00652-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S181808"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S240607"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00664-x"},{"key":"e_1_2_8_13_1","first-page":"669","article-title":"Generalized pustular psoriasis (Zumbusch): a French epidemiological survey","volume":"16","author":"Augey F","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1252022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00654-z"},{"key":"e_1_2_8_16_1","unstructured":"FeldmanS KotowskyN GaoR et\u00a0al.Prevalence of generalized pustular psoriasis in the USA: Results from multiple administrative claims databases. presented at: 30th European Academy of Dermatology and Venereology Congress; 29 September\u20132 October 20212021;Virtual."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20966"},{"key":"e_1_2_8_18_1","unstructured":"GesundheitBf.GKV\u2010Mitglieder mitversicherte Angeh\u00f6rige Beitragss\u00e4tze und Krankenstand. Available from:https:\/\/www.bundesgesundheitsministerium.de\/themen\/krankenversicherung\/zahlen\u2010und\u2010fakten\u2010zur\u2010krankenversicherung\/mitglieder\u2010und\u2010versicherte.html(Last accessed August 3 2023)."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00661-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12070"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14764"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2020.1831315"},{"key":"e_1_2_8_23_1","first-page":"61","volume-title":"Generalized pustular psoriasis in Brazil: A public claims database study","author":"Duarte G","year":"2022"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528850"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006450"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2017.29.6.761"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ddg.15633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:00:06Z","timestamp":1789981206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/ddg.15633"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15633","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"2023-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}