{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:31:36Z","timestamp":1790271096249,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Linear immunoglobulin A (IgA) bullous dermatosis (LABD), also referred to as chronic bullous disease of childhood (CBDC), is characterized by the linear deposition of IgA antibodies within the dermal\u2010epidermal junction. While dapsone is typically recommended, alternative modalities may be considered based on accessibility, severity, and prior response to therapy. This review aims to provide an updated overview of the clinical characteristics and treatment outcomes for LABD\/CBDC. A systematic review was conducted using MEDLINE and Embase in adherence to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis guidelines. Results from 650 articles, encompassing 1,627 cases, revealed 52% of cases were male. Vesicles (49%) and bullae (47%) were the predominant morphologies occurring across multiple body locations simultaneously, such as the legs (52%), abdomen (49%), and back (49%). Vancomycin was the most reported causative medication; however, most cases were not drug\u2010induced. Dapsone was the primary therapy for LABD\/CBDC while biologics were reported with higher complete response rates. Other immunomodulators, such as IVIG and mycophenolate mofetil, were reported to have comparative responses in CBDC cases, but lower response rates in LABD cases. Colchicine and amoxicillin\u2010clavulanate had lower response rates overall. The variety of treatment options underscores management challenges due to the variable clinical presentations and underlying causes.<\/jats:p>","DOI":"10.1111\/ddg.15644","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:16:09Z","timestamp":1741745769000},"page":"576-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical characteristics and treatment outcomes of linear IgA bullous dermatosis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-8633","authenticated-orcid":false,"given":"Kristie","family":"Mar","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Landells","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Memorial University of Newfoundland  St. John's Newfoundland and Labrador Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Khalid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswen","family":"Sriranganathan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Y.","family":"Starkey","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital Delaware  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan V.","family":"Litvinov","sequence":"additional","affiliation":[{"name":"Department of Dermatology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-9413","authenticated-orcid":false,"given":"Ilya","family":"Mukovozov","sequence":"additional","affiliation":[{"name":"Toronto Dermatology Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Linear IGA dermatosis","author":"Bernett 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