{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T10:29:48Z","timestamp":1764584988192,"version":"3.46.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The strength of evidence supporting a 2\u2010step wide local excision (WLE) with 5\u00a0mm safety margins for melanoma in situ non\u2010lentigo maligna (non\u2010LM) type, compared with narrower margins, is unclear. This review aims to compare the frequency of local recurrence (LR) with different safety margins, after the complete surgical excision (R0) of non\u2010LM MIS. We performed a systematic literature search in PubMed, Scopus, and the Cochrane Library up to March 17, 2024. The PRISMA checklist was used. Of 3,047 articles retrieved, seven retrospective studies were included, enrolling a total of 1,526 non\u2010LM MIS cases excised with clear safety margins, after WLE (6 studies) or Mohs surgery (1 study). Most non\u2010LM MIS were located on the trunk\/extremities (68%\u2013100%). Narrower margins were used in four studies, ranging from no WLE to 4\u00a0mm, and there was only one LR. Standard or wider margins were used in the remaining three studies reporting only two LR. The median follow\u2010up ranged from 48\u00a0months to 6.6\u00a0years. The overall certainty and quality of evidence were very low. These findings of our systematic review highlight that current guidelines recommending the re\u2010excision for non\u2010LM MIS with clear initial margins lack strong evidence in support of this practice.<\/jats:p>","DOI":"10.1111\/ddg.15699","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T06:23:17Z","timestamp":1744698197000},"page":"805-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Local recurrence of non\u2010lentigo maligna melanoma in situ and safety excision margins: A systematic review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-3410","authenticated-orcid":false,"given":"Clio","family":"Dessinioti","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology National and Kapodistrian University of Athens Andreas Sygros Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggeliki","family":"Befon","sequence":"additional","affiliation":[{"name":"State Department of Dermatology\u2010Venereology Andreas Sygros Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J","family":"Stratigos","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology National and Kapodistrian University of Athens Andreas Sygros Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.067"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.12.024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.1494"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.0706"},{"key":"e_1_2_6_7_1","unstructured":"SwetterSM JohnsonD AlbertiniMR et\u00a0al.NCCN Guidelines. 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