{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:02:58Z","timestamp":1781877778586,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Knowledge on patient care gaps of prurigo nodularis (PN) is limited. This retrospective chart review (ADVANCE PN) investigated unmet medical needs and gaps in diagnostics, treatment, and management of patients with PN in routine care in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Medical records for adults newly diagnosed with PN between January 2012 and December 2022 from dermatologic clinics and office\u2010based dermatologists were analyzed. Baseline demographics, treatment patterns, diagnostics, symptoms, patient\u2010reported outcomes (PROs), and disease\u2010specific scores are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Records of 363 patients from 42 sites were analyzed. Median age (range) was 67 (19\u201395) years; most patients were female (61.7%), Caucasian (73.4%), and retired (57.3%). Overall, 209 (62.2%) patients had comorbidities (most common: hypertension [28.3%]). Clinically, most patients had nodules (81.1%) or papules (66.7%). PROs, disease\u2010specific scores, and laboratory assessments were performed for 32 (8.8%), 12 (3.3%), and 71 (19.7%) patients, respectively. Topical corticosteroids (TCS) were the most common overall (90.9%) and first\u2010line therapy (84.9%); for second\u2010line therapy, \u2018no further treatment\u2019 was most commonly documented (58.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of ADVANCE PN indicate a high unmet need in the current state of medical care, evidenced by shortcomings in PRO assessment, PN documentation, and adherence to guidelines on PN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15721","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T22:35:43Z","timestamp":1749422143000},"page":"844-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of routine care of prurigo nodularis in Germany: retrospective chart review study (ADVANCE PN)"],"prefix":"10.1111","volume":"23","author":[{"given":"Ralph","family":"von Kiedrowski","sequence":"first","affiliation":[{"name":"Company for Medical Study &amp; Service Selters and Private Practice Dermatology  Selters\/Westerwald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-9976","authenticated-orcid":false,"given":"Martin","family":"Metz","sequence":"additional","affiliation":[{"name":"Institute of Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Immunology and Allergy  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Division of Occupational Dermatology Department of Dermatology Ruprecht\u2010Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6384-662X","authenticated-orcid":false,"given":"Inka","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis Deutschland GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Schild","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis Deutschland GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-7786","authenticated-orcid":false,"given":"Sonja","family":"St\u00e4nder","sequence":"additional","affiliation":[{"name":"Center for Chronic Pruritus and Section for Pruritus Medicine of the Department of Dermatology M\u00fcnster University Hospital  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2774"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.182"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.04.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3655"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14830"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/itx.0000000000000042"},{"key":"e_1_2_9_8_1","unstructured":"US Food and Drug Administration.Dupixent\u00ae (dupilumab) injection for subcutaneous use.2017. 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