{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:16:59Z","timestamp":1788016619944,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Continuous biologic treatment is recommended for patients with psoriasis; however, treatment interruption in daily practice is inevitable. The impact of treatment interruption is difficult to study in a real\u2010world setting. In Taiwan, biologics are reimbursed by the National Health Insurance for moderate\u2010to\u2010severe psoriasis for a 2\u2010year course, followed by regulatory discontinuation. Thus, our study provides pragmatic data on the impact of the interruption of biologics treatment for non\u2010medical reasons on therapy effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This single\u2010center retrospective cohort study recruited patients who underwent two consecutive 2\u2010year courses of biologics between 2012 to 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 192 treatment courses from 61 patients were analyzed, with secukinumab and ustekinumab being the most frequently administered biologics. Among patients who continued with the same biologic across two consecutive courses, the time to achieve PASI\u00a075 was shorter during the first course compared to the second, while overall maintenance effects remained similar. Switching to a different biologic usually produced superior results in the second course of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the overall effectiveness after interruption and resumption of treatment with secukinumab or ustekinumab was comparable, the time to achieve PASI\u00a075 was longer following an interruption. Continuous, uninterrupted treatment with a given biologic is therefore recommended whenever possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.15787","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:09:18Z","timestamp":1753708158000},"page":"1106-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimizing biologics for chronic plaque psoriasis: insights on non\u2010medical interruptions of IL\u201017, IL\u201012\/23, and IL\u201023 inhibitors"],"prefix":"10.1111","volume":"23","author":[{"given":"Hsin\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Tainan Hospital Ministry of Health and Welfare  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Lun","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-6522","authenticated-orcid":false,"given":"Chao\u2010Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak\u2010Wah","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Chia\u2010Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Pharmacy Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Population Health Data Center National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-0657","authenticated-orcid":false,"given":"Chaw\u2010Ning","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Pharmacy Institute of Clinical Pharmacy and Pharmaceutical Sciences College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Population Health Data Center National Cheng Kung University  Tainan 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