{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T14:19:04Z","timestamp":1765462744892,"version":"3.48.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Panallergen families differ in their stability to heat and pH, which affects both the severity and clinical manifestations of allergic reactions. The extent of epithelial barrier dysfunction is thought to influence sensitization to different allergens. This study aimed to investigate associations between patient characteristics, epithelial barrier\u2010related markers, and distinct sensitization profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Specific immunoglobulin E (sIgE) against stable (2S albumins, 7\/8S and 11S globulins) and unstable allergens (PR\u201010 proteins, profilins) was assessed in 216 patients recruited in South Tyrol, Italy, using the multiplex assay ALEX\n                      <jats:sup>2<\/jats:sup>\n                      and correlated with patient demographics, allergic symptoms,\n                      <jats:italic>Investigator Global Assessment Score<\/jats:italic>\n                      (IGA score),\n                      <jats:italic>Transepidermal Water Loss<\/jats:italic>\n                      (TEWL), and\n                      <jats:italic>Fractional exhaled Nitric Oxide<\/jats:italic>\n                      (FeNO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients sensitized to stable allergens were younger, showed more frequently eczema, higher IGA scores, and higher TEWL. Gastrointestinal symptoms combined with skin symptoms were more common. Respiratory symptoms alone were more frequent in patients sensitized to unstable allergens but were associated with higher FeNO values only in the case of co\u2010sensitizations to stable allergens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sensitization to stable allergens is associated with distinctive epithelial barrier impairment. Children with respiratory symptoms may benefit from multiplex testing for co\u2010sensitizations to stable food allergens and early initiation of specific immunotherapy to aeroallergens to prevent asthma in positive cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15810","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T06:24:56Z","timestamp":1754720696000},"page":"1544-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of allergen stability and epithelial barrier function in sensitized patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-7345","authenticated-orcid":false,"given":"Hannes","family":"N\u00f6sslinger","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics Hospital of Merano (SABES\u2010ASDAA) Teaching Hospital of Paracelsus Medical University  Merano\u2010Meran Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-7133","authenticated-orcid":false,"given":"Ewald","family":"Mair","sequence":"additional","affiliation":[{"name":"Registered pediatrician (SABES\u2010ASDAA)  Brunico\u2010Bruneck Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-217X","authenticated-orcid":false,"given":"Gertie Janneke","family":"Oostingh","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Salzburg University of Applied Sciences  Puch\/Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4187-0662","authenticated-orcid":false,"given":"Verena","family":"Ahlgrimm\u2010Siess","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ringauf","sequence":"additional","affiliation":[{"name":"MacroArray Diagnostics (MADx)  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-0188","authenticated-orcid":false,"given":"Roland","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1186\/1710-1492-6-1"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"213","article-title":"Pollen\u2010food allergy syndrome (PFAS)","volume":"35","author":"Lloyd M","year":"2022","journal-title":"Curr Allergy Clin Immunol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1111\/pai.12589"},{"key":"e_1_2_8_5_1","first-page":"454","volume-title":"Molecular Allergology User's Guide 2.0","author":"Hoffmann K","year":"2022"},{"key":"e_1_2_8_6_1","first-page":"526","volume-title":"Molecular Allergology User's Guide 2.0","author":"Hoffmann K","year":"2022"},{"key":"e_1_2_8_7_1","first-page":"395","volume-title":"Molecular Allergology User's Guide 2.0","author":"Hoffmann K","year":"2022"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1111\/all.13501"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.3389\/fmolb.2022.900533"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1038\/s41577-021-00538-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1016\/j.jaad.2020.04.104"},{"unstructured":"MacroArray Diagnostics.Allergy & food intolerance multiplex testing. 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Available from:https:\/\/www.medundorg.de\/shop\/Praxisorganisation\/Formularwesen\/Ernaehrungsberatung\/QUETHEB\u2010Allergieanamnese.html[Last accessed on February 9 2022].","key":"e_1_2_8_13_1"},{"issue":"6","key":"e_1_2_8_14_1","first-page":"4","article-title":"Fractional exhaled nitric oxide testing: diagnostic utility in asthma, chronic obstructive pulmonary disease, or asthma\u2010chronic obstructive pulmonary disease overlap syndrome","volume":"11","author":"Miskoff JA","year":"2019","journal-title":"Cureus"},{"volume-title":"Practical nonparametric statistics","year":"1999","author":"Conover WJ","key":"e_1_2_8_15_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1016\/j.jaci.2013.12.1071"},{"issue":"2","key":"e_1_2_8_17_1","first-page":"1","article-title":"The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma","volume":"5","author":"Bantz S","year":"2014","journal-title":"J Clin Cell Immunol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1111\/cea.13866"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.3390\/children8111067"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1542\/peds.101.3.e8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1097\/CM9.0000000000001983"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1111\/all.15170"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1159\/000324440"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1111\/all.14140"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.3389\/fphys.2021.691227"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.1111\/all.14421"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.15586\/aei.v49i1.19"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1111\/all.12345"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T14:15:16Z","timestamp":1765462516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ddg.15810"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15810","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"type":"print","value":"1610-0379"},{"type":"electronic","value":"1610-0387"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"2025-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}