{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:10:15Z","timestamp":1785161415379,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Atopic dermatitis (AD) and thyroid diseases share features of immune dysregulation, but their association has not yet been comprehensively analyzed. We aimed to systematically investigate the association of AD with thyroid diseases. A systematic review and random\u2010effects model meta\u2010analysis of observational studies was conducted. We searched MEDLINE, Embase, and CENTRAL for relevant studies until April 12, 2024. The risk of bias was assessed using the Newcastle\u2010Ottawa Scale. A subgroup analysis based on age was performed. Twelve observational studies with 93,547,813 subjects were included. The meta\u2010analysis of ten case\u2010control studies revealed significant association of AD with prevalent thyroid diseases (odds ratio [OR]1.48; 95% confidence interval [CI] 1.17\u20131.88), including Hashimoto disease (OR 2.13; 95%\u00a0CI 1.33\u20133.43) and Graves\u2019 disease (OR 1.56; 95%\u00a0CI 1.03\u20132.37). Pediatric patients exhibited a stronger association (OR 1.88; 95%\u00a0CI 1.48\u20132.37) than adults (OR 1.34; 95%\u00a0CI 1.00\u20131.80). Two cohort studies demonstrated that AD patients had increased risks of incident thyroid diseases (incidence risk ratio 1.13; 95%\u00a0CI 1.05\u20131.22) and Hashimoto disease (hazard ratio 1.17; 95%\u00a0CI 1.09\u20131.25). In conclusion, AD is associated with thyroid diseases, notably in pediatric patients, warranting endocrinological consultation and early intervention to mitigate potential impacts on growth and cognitive development.<\/jats:p>","DOI":"10.1111\/ddg.15823","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T08:39:01Z","timestamp":1754123941000},"page":"1072-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of atopic dermatitis with thyroid diseases: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Yen\u2010Ning","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital Linkou Main Branch  Taoyuan Taiwan"},{"name":"Department of Medical Education Chang Gung Memorial Hospital Linkou Main Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-5030","authenticated-orcid":false,"given":"Tzu\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"E\u2010Champ Taipei Clinic  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Chen","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital Linkou Main Branch  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-0283","authenticated-orcid":false,"given":"Ching\u2010Chi","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital Linkou Main Branch  Taoyuan Taiwan"},{"name":"School of Medicine College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad339"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.028"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.05.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00149-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-00992-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3324"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.130"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-021-00597-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.1.3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12274"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_17_1","unstructured":"WellsG Shea B O'Connell D et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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