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Due to the its rarity, there are no standardized treatment guidelines for this disease, making treatment in everyday clinical practice more difficult.<\/jats:p><jats:p>The aim of this study was therefore to summarize the therapeutic experience of the last 22\u00a0years by conducting a systematic literature review and thus generate an overview of the various treatment options. A systematic literature review on the topic of xanthoma disseminatum and applied treatment strategies was conducted in the PubMed\/MEDLINE database for the period from 26 June 2002 to 26 June 2024.<\/jats:p><jats:p>The literature search resulted in 38 publications, 19 of which were included in the review. The therapeutic approaches of the studies analyzed can be divided into immunosuppressive, cytostatic\u2010based, lipid\u2010lowering, surgical, UV radiation, and laser\u2010based therapeutic approaches. Therapy with cladribine was reported most frequently. The current data is mainly based on case reports and case series, which are presented and summarized in this review. It can therefore be used as a basis for treatment decisions.<\/jats:p>","DOI":"10.1111\/ddg.15824","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T05:03:56Z","timestamp":1754715836000},"page":"1061-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Xanthoma disseminatum \u2013 a systematic literature review"],"prefix":"10.1111","volume":"23","author":[{"given":"Inga","family":"Hansen\u2010Abeck","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Hillemans","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Hamburg\u2010Eppendorf  Hamburg 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